Background: It has been largely shown that during the first month of life, in the preterm neonate Hb levels and Hct percentages rapidly decrease, high HbF concentration persists and a high oxygen affinity occurs. Data are needed to establish the level at which 2,3 dyphosphoglycerate (2,3 DPG) interacts with the regulation of oxygen affinity. Subjects and methods: 24 samples, from eight uncomplicated preterm newborns (34.1 ± 1.83 GW, 1869 ± ±291 BW) obtained at the same time as those required for the clinical management of the infants, were collected on the 2 nd, 7 th and 14 th day of life. Blood gases, total hemoglobin and hematocrit were obtained from 0.3ml arterialised capillary blood. Assays of 2,3 DPG were made separately on 0,4 ml venous blood. Results: As expected tHb concentration and Hct percentages significantly decreased from day2 to day4 in all eight cases. On the contrary 2,3 DPG and p50 values remained stable. Subsequently throughout the study period all neonates had an increased 2,3DPG/Hb ratio that was significantly related with p50 at standard conditions (p <0.05). Conclusions: Stable 2,3 DPG concentrations during all study period have been detected. The subsequent significant increased 2.3DPG/Hb, ratio related to increased p50 values, could have a key role in a physiological mechanism aimed to ensure adequate oxygen delivery to the tissues and to counteract the higher oxygen affinity of fetal hemoglobin. A wider sample is needed to validate this hypothesis.
|Translated title of the contribution||2,3 dyphosphoglycerate in the prêterai newborn|
|Number of pages||6|
|Issue number||SUPPL. 1|
|Publication status||Published - 2000|
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