TY - JOUR
T1 - 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) role in hematopoiesis and in hematologic diseases
T2 - A critical review
AU - Fracchiolla, Nicola Stefano
AU - Annaloro, Claudio
AU - Guidotti, Francesca
AU - Fattizzo, Bruno
AU - Cortelezzi, Agostino
PY - 2016/12/30
Y1 - 2016/12/30
N2 - Dioxin exposure and its effect on hematopoiesis and cancer have been largely investigated in both human and non-human settings. Here we systematically reviewed literature to address the question of what we know about TCDD biology and exposure. Most effects are due to TCDD interaction with a receptor of xenobiotics called AHR, which is ubiquitously represented and also works on hematopoietic myeloid and lymphoid stem cells, inducing proliferation and stem cell release from bone marrow to peripheral circulation. Epidemiologic studies on TCDD exposure demonstrated an association with onco-hematologic diseases, particularly with non Hodgkin lymphomas and multiple myeloma, and non hematologic cancers, such as sarcomas, although these relationships are affected by multiple confounding factors.
AB - Dioxin exposure and its effect on hematopoiesis and cancer have been largely investigated in both human and non-human settings. Here we systematically reviewed literature to address the question of what we know about TCDD biology and exposure. Most effects are due to TCDD interaction with a receptor of xenobiotics called AHR, which is ubiquitously represented and also works on hematopoietic myeloid and lymphoid stem cells, inducing proliferation and stem cell release from bone marrow to peripheral circulation. Epidemiologic studies on TCDD exposure demonstrated an association with onco-hematologic diseases, particularly with non Hodgkin lymphomas and multiple myeloma, and non hematologic cancers, such as sarcomas, although these relationships are affected by multiple confounding factors.
KW - 2,3,7,8-Tetrachlorodibenzo-p-dioxin
KW - Aryl hydrocarbon receptor
KW - Hematopoiesis
KW - non Hodgkin lymphoma
UR - http://www.scopus.com/inward/record.url?scp=84999264493&partnerID=8YFLogxK
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U2 - 10.1016/j.tox.2016.10.007
DO - 10.1016/j.tox.2016.10.007
M3 - Review article
AN - SCOPUS:84999264493
VL - 374
SP - 60
EP - 68
JO - Toxicology
JF - Toxicology
SN - 0300-483X
ER -