24. Secreting germ cell tumors of the central nervous system (CNS). First results of the cooperative german/italian pilot study (CNS s GCT)

G. Calaminus, L. Andreussi, M. L. Garrè, R. Dieter Kortmann, R. Schober, G. Perilongo, U. Gobel

Research output: Contribution to journalArticlepeer-review


Background. Secreting germ cell tumors are an invariably fatal subgroup within the malignant paediatric brain tumors. Thus in 1993, an international working group was initiated to establish a cooperative study for diagnostic and treatment of intracranial secreting germ cell tumors of the CNS. To pilot this protocol, since 1994 German and Italian patients are treated in accordance with the established guidelines. Methods. Regarding to the achieved consensus within the international protocol committee a characteristical diagnostic imaging (CT/MRI scan) of head and spine and a significant increase of tumor markers beta-HCG (> 50 IU/I) and/or AFP (> 25ng/ml) are defined as sufficient diagnostic criteria. Additionally staging procedures include an initial CSF cytology. Treatment consists of 4 courses PEI: platinum (20 mg/m2 day 1-5), VP16 (100 mg/m2 day 1-3), and ifosfamide (1.5 g/m2 day 1-5). Surgery of the residual tumor is administered after chemotherapy followed by craniospinal irradiation (30 Gy with tumor boost 20 Gy). Results. Until September 96, 19 patients (16 boys and 3 girls) aged 8 to 19 years are registered and have finished their treatment. In 13/19 cases primary site involved the pineal area. Seven children are diagnosed by elevated tumor markers. In 6 patients, the tumor is primarily resected, 6 children are biopsied. In 2 children spinal metastases are diagnosed initially. Tumor marker response is evaluated in 16 children. Thirteen of 16 patients show a clear marker normalisation after 2 courses of PEI. One boy with a slight increase of the tumor marker after 4th course developed an early spinal relapse and died. One girl showed a spinal recurrence during focal radiotherapy. A significant decrease of tumor volume is documented in 10/13. In 3 children tumor volume does not change despite of marker normalisation. Histology of these tumors is teratoma. One of these children died postoperatively because of tumor bleeding. 17/19 patients are alive, 16 of them are in complete remission with a median follow-up of 11 months. Conclusion. These results show a further significant increase of event-free survival (EFS 81%). The piloted chemotherapy is proven to be effective and the protocol is now open as an international SIOP CNS GCT study that is started in October 1996.

Original languageEnglish
Pages (from-to)247-248
Number of pages2
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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