Abstract
A few 2, 6-disubstituted benzothiazoles have been prepared as reference compounds or starting material for the preparation of derivatives containing positron emitting fluorine in the aromatic ring. Their affinity for Photinus pyralis luciferase has been evaluated and values of IC50 (8.8-45.2 μM) suggest that they are competitive inhibitors of the enzyme.
Original language | English |
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Pages (from-to) | 22-30 |
Number of pages | 9 |
Journal | Arkivoc |
Volume | 2009 |
Issue number | 11 |
Publication status | Published - 2009 |
Keywords
- 2,6-disubstituted benzothiazoles
- D-luciferin
- Luciferase
ASJC Scopus subject areas
- Organic Chemistry