Abstract
A few 2, 6-disubstituted benzothiazoles have been prepared as reference compounds or starting material for the preparation of derivatives containing positron emitting fluorine in the aromatic ring. Their affinity for Photinus pyralis luciferase has been evaluated and values of IC50 (8.8-45.2 μM) suggest that they are competitive inhibitors of the enzyme.
| Original language | English |
|---|---|
| Pages (from-to) | 22-30 |
| Number of pages | 9 |
| Journal | Arkivoc |
| Volume | 2009 |
| Issue number | 11 |
| Publication status | Published - 2009 |
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Keywords
- 2,6-disubstituted benzothiazoles
- D-luciferin
- Luciferase
ASJC Scopus subject areas
- Organic Chemistry
Cite this
2,6-Disubstituted benzothiazoles, analogues of the aromatic core of D-luciferin : Synthesis and evaluation of the affinity for Photinus pyralis luciferase. / Meroni, Giuseppe; Ciana, Paolo; Meda, Clara; Maggi, Adriana; Santanielloa, Enzo.
In: Arkivoc, Vol. 2009, No. 11, 2009, p. 22-30.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 2,6-Disubstituted benzothiazoles, analogues of the aromatic core of D-luciferin
T2 - Synthesis and evaluation of the affinity for Photinus pyralis luciferase
AU - Meroni, Giuseppe
AU - Ciana, Paolo
AU - Meda, Clara
AU - Maggi, Adriana
AU - Santanielloa, Enzo
PY - 2009
Y1 - 2009
N2 - A few 2, 6-disubstituted benzothiazoles have been prepared as reference compounds or starting material for the preparation of derivatives containing positron emitting fluorine in the aromatic ring. Their affinity for Photinus pyralis luciferase has been evaluated and values of IC50 (8.8-45.2 μM) suggest that they are competitive inhibitors of the enzyme.
AB - A few 2, 6-disubstituted benzothiazoles have been prepared as reference compounds or starting material for the preparation of derivatives containing positron emitting fluorine in the aromatic ring. Their affinity for Photinus pyralis luciferase has been evaluated and values of IC50 (8.8-45.2 μM) suggest that they are competitive inhibitors of the enzyme.
KW - 2,6-disubstituted benzothiazoles
KW - D-luciferin
KW - Luciferase
UR - http://www.scopus.com/inward/record.url?scp=77953189127&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953189127&partnerID=8YFLogxK
M3 - Article
VL - 2009
SP - 22
EP - 30
JO - Arkivoc
JF - Arkivoc
SN - 1424-6376
IS - 11
ER -