2,6-Disubstituted benzothiazoles, analogues of the aromatic core of D-luciferin: Synthesis and evaluation of the affinity for Photinus pyralis luciferase

Giuseppe Meroni; Paolo Ciana; Clara Meda; Adriana Maggi; Enzo Santanielloa

2,6-Disubstituted benzothiazoles, analogues of the aromatic core of D-luciferin: Synthesis and evaluation of the affinity for Photinus pyralis luciferase

Giuseppe Meroni, Paolo Ciana, Clara Meda, Adriana Maggi, Enzo Santanielloa

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

A few 2, 6-disubstituted benzothiazoles have been prepared as reference compounds or starting material for the preparation of derivatives containing positron emitting fluorine in the aromatic ring. Their affinity for Photinus pyralis luciferase has been evaluated and values of IC₅₀ (8.8-45.2 μM) suggest that they are competitive inhibitors of the enzyme.

Original language	English
Pages (from-to)	22-30
Number of pages	9
Journal	Arkivoc
Volume	2009
Issue number	11
Publication status	Published - 2009

Keywords

2,6-disubstituted benzothiazoles
D-luciferin
Luciferase

ASJC Scopus subject areas

Organic Chemistry

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abstract = "A few 2, 6-disubstituted benzothiazoles have been prepared as reference compounds or starting material for the preparation of derivatives containing positron emitting fluorine in the aromatic ring. Their affinity for Photinus pyralis luciferase has been evaluated and values of IC50 (8.8-45.2 μM) suggest that they are competitive inhibitors of the enzyme.",

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T2 - Synthesis and evaluation of the affinity for Photinus pyralis luciferase

AU - Meroni, Giuseppe

AU - Ciana, Paolo

AU - Meda, Clara

AU - Maggi, Adriana

AU - Santanielloa, Enzo

PY - 2009

Y1 - 2009

N2 - A few 2, 6-disubstituted benzothiazoles have been prepared as reference compounds or starting material for the preparation of derivatives containing positron emitting fluorine in the aromatic ring. Their affinity for Photinus pyralis luciferase has been evaluated and values of IC50 (8.8-45.2 μM) suggest that they are competitive inhibitors of the enzyme.

AB - A few 2, 6-disubstituted benzothiazoles have been prepared as reference compounds or starting material for the preparation of derivatives containing positron emitting fluorine in the aromatic ring. Their affinity for Photinus pyralis luciferase has been evaluated and values of IC50 (8.8-45.2 μM) suggest that they are competitive inhibitors of the enzyme.

KW - 2,6-disubstituted benzothiazoles

KW - D-luciferin

KW - Luciferase

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