2,6-Disubstituted benzothiazoles, analogues of the aromatic core of D-luciferin: Synthesis and evaluation of the affinity for Photinus pyralis luciferase

Giuseppe Meroni, Paolo Ciana, Clara Meda, Adriana Maggi, Enzo Santanielloa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A few 2, 6-disubstituted benzothiazoles have been prepared as reference compounds or starting material for the preparation of derivatives containing positron emitting fluorine in the aromatic ring. Their affinity for Photinus pyralis luciferase has been evaluated and values of IC50 (8.8-45.2 μM) suggest that they are competitive inhibitors of the enzyme.

Original languageEnglish
Pages (from-to)22-30
Number of pages9
JournalArkivoc
Volume2009
Issue number11
Publication statusPublished - 2009

Fingerprint

Benzothiazoles
Fluorine
Positrons
Enzyme Inhibitors
Derivatives
Photinus luciferase
D-luciferin

Keywords

  • 2,6-disubstituted benzothiazoles
  • D-luciferin
  • Luciferase

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

2,6-Disubstituted benzothiazoles, analogues of the aromatic core of D-luciferin : Synthesis and evaluation of the affinity for Photinus pyralis luciferase. / Meroni, Giuseppe; Ciana, Paolo; Meda, Clara; Maggi, Adriana; Santanielloa, Enzo.

In: Arkivoc, Vol. 2009, No. 11, 2009, p. 22-30.

Research output: Contribution to journalArticle

Meroni, Giuseppe ; Ciana, Paolo ; Meda, Clara ; Maggi, Adriana ; Santanielloa, Enzo. / 2,6-Disubstituted benzothiazoles, analogues of the aromatic core of D-luciferin : Synthesis and evaluation of the affinity for Photinus pyralis luciferase. In: Arkivoc. 2009 ; Vol. 2009, No. 11. pp. 22-30.
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