2D TR-NOESY experiments interrogate and rank ligand-receptor interactions in living human cancer cells

Silvia Mari, Chiara Invernizzi, Andrea Spitaleri, Luca Alberici, Michela Ghitti, Claudio Bordignon, Catia Traversari, Gian Paolo Rizzardi, Giovanna Musco

Research output: Contribution to journalArticlepeer-review

Abstract

(Figure Presented) Cell mates: Various ligand-receptor interactions in different human cancer cell lines were probed directly by two-dimensional transferred-NOE spectroscopy (see picture) to prove recognition specificity and determine an affinity ranking of several ligands.

Original languageEnglish
Pages (from-to)1071-1074
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number6
DOIs
Publication statusPublished - Feb 1 2010

Keywords

  • Drug design
  • Integrins
  • Nmr spectroscopy
  • Protein-ligand interactions

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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