2D TR-NOESY experiments interrogate and rank ligand-receptor interactions in living human cancer cells

Silvia Mari, Chiara Invernizzi, Andrea Spitaleri, Luca Alberici, Michela Ghitti, Claudio Bordignon, Catia Traversari, Gian Paolo Rizzardi, Giovanna Musco

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

(Figure Presented) Cell mates: Various ligand-receptor interactions in different human cancer cell lines were probed directly by two-dimensional transferred-NOE spectroscopy (see picture) to prove recognition specificity and determine an affinity ranking of several ligands.

Original languageEnglish
Pages (from-to)1071-1074
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number6
DOIs
Publication statusPublished - Feb 1 2010

Fingerprint

Ligands
Cells
Experiments
Spectroscopy

Keywords

  • Drug design
  • Integrins
  • Nmr spectroscopy
  • Protein-ligand interactions

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

2D TR-NOESY experiments interrogate and rank ligand-receptor interactions in living human cancer cells. / Mari, Silvia; Invernizzi, Chiara; Spitaleri, Andrea; Alberici, Luca; Ghitti, Michela; Bordignon, Claudio; Traversari, Catia; Rizzardi, Gian Paolo; Musco, Giovanna.

In: Angewandte Chemie - International Edition, Vol. 49, No. 6, 01.02.2010, p. 1071-1074.

Research output: Contribution to journalArticle

Mari, S, Invernizzi, C, Spitaleri, A, Alberici, L, Ghitti, M, Bordignon, C, Traversari, C, Rizzardi, GP & Musco, G 2010, '2D TR-NOESY experiments interrogate and rank ligand-receptor interactions in living human cancer cells', Angewandte Chemie - International Edition, vol. 49, no. 6, pp. 1071-1074. https://doi.org/10.1002/anie.200905941
Mari, Silvia ; Invernizzi, Chiara ; Spitaleri, Andrea ; Alberici, Luca ; Ghitti, Michela ; Bordignon, Claudio ; Traversari, Catia ; Rizzardi, Gian Paolo ; Musco, Giovanna. / 2D TR-NOESY experiments interrogate and rank ligand-receptor interactions in living human cancer cells. In: Angewandte Chemie - International Edition. 2010 ; Vol. 49, No. 6. pp. 1071-1074.
@article{c421964d286a422fadaf8a2e16420089,
title = "2D TR-NOESY experiments interrogate and rank ligand-receptor interactions in living human cancer cells",
abstract = "(Figure Presented) Cell mates: Various ligand-receptor interactions in different human cancer cell lines were probed directly by two-dimensional transferred-NOE spectroscopy (see picture) to prove recognition specificity and determine an affinity ranking of several ligands.",
keywords = "Drug design, Integrins, Nmr spectroscopy, Protein-ligand interactions",
author = "Silvia Mari and Chiara Invernizzi and Andrea Spitaleri and Luca Alberici and Michela Ghitti and Claudio Bordignon and Catia Traversari and Rizzardi, {Gian Paolo} and Giovanna Musco",
year = "2010",
month = "2",
day = "1",
doi = "10.1002/anie.200905941",
language = "English",
volume = "49",
pages = "1071--1074",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "6",

}

TY - JOUR

T1 - 2D TR-NOESY experiments interrogate and rank ligand-receptor interactions in living human cancer cells

AU - Mari, Silvia

AU - Invernizzi, Chiara

AU - Spitaleri, Andrea

AU - Alberici, Luca

AU - Ghitti, Michela

AU - Bordignon, Claudio

AU - Traversari, Catia

AU - Rizzardi, Gian Paolo

AU - Musco, Giovanna

PY - 2010/2/1

Y1 - 2010/2/1

N2 - (Figure Presented) Cell mates: Various ligand-receptor interactions in different human cancer cell lines were probed directly by two-dimensional transferred-NOE spectroscopy (see picture) to prove recognition specificity and determine an affinity ranking of several ligands.

AB - (Figure Presented) Cell mates: Various ligand-receptor interactions in different human cancer cell lines were probed directly by two-dimensional transferred-NOE spectroscopy (see picture) to prove recognition specificity and determine an affinity ranking of several ligands.

KW - Drug design

KW - Integrins

KW - Nmr spectroscopy

KW - Protein-ligand interactions

UR - http://www.scopus.com/inward/record.url?scp=76249115142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76249115142&partnerID=8YFLogxK

U2 - 10.1002/anie.200905941

DO - 10.1002/anie.200905941

M3 - Article

C2 - 20058288

AN - SCOPUS:76249115142

VL - 49

SP - 1071

EP - 1074

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 6

ER -