(2S,1′R,2′R,3′R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices

Ferdinando Nicoletti, Giacomo Casabona, Armando A. Genazzani, Maria Rita L'Episcopo, Haruhiko Shinozaki

Research output: Contribution to journalArticlepeer-review

Abstract

In adult rat hippocampal slices,(2S,1′R,2′R,3′R)-2-(2,3-dicarboxyxyclopropyl)glycine (DCG-IV) did not affect the basal hydrolysis of polyphosphoinositides but dramatically enhanced (EC50 value = 30 nM the stimulation of [3H]inositol monophosphate (InsP) formation by quisqualate, without substantially affecting the stimulation produced by maximal concentrations of 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (ACPD) or carbamylcholine. α-Amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) was virtually devoid of activity on [3H]InsP formation, either in the absence or presence of DCG-IV. These results suggest that DCG-IV acts, directly or indirectly, as a positive modulator of metabotropic glutamate receptors in the rat hippocampus.

Original languageEnglish
Pages (from-to)297-298
Number of pages2
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume245
Issue number3
DOIs
Publication statusPublished - May 15 1993

Keywords

  • (Hippocampal slices)
  • dicarboxycyclopropylglycine
  • Metabotropic glutamate receptors
  • quisqualate

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of '(2S,1′R,2′R,3′R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices'. Together they form a unique fingerprint.

Cite this