In adult rat hippocampal slices,(2S,1′R,2′R,3′R)-2-(2,3-dicarboxyxyclopropyl)glycine (DCG-IV) did not affect the basal hydrolysis of polyphosphoinositides but dramatically enhanced (EC50 value = 30 nM the stimulation of [3H]inositol monophosphate (InsP) formation by quisqualate, without substantially affecting the stimulation produced by maximal concentrations of 1S,3R-aminocyclopentane-1,3-dicarboxylic acid (ACPD) or carbamylcholine. α-Amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) was virtually devoid of activity on [3H]InsP formation, either in the absence or presence of DCG-IV. These results suggest that DCG-IV acts, directly or indirectly, as a positive modulator of metabotropic glutamate receptors in the rat hippocampus.
|Number of pages||2|
|Journal||European Journal of Pharmacology: Molecular Pharmacology|
|Publication status||Published - May 15 1993|
- (Hippocampal slices)
- Metabotropic glutamate receptors
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience