TY - JOUR
T1 - 3-Aminobenzamide induces cytoskeleton rearrangement in M14 melanoma cells
AU - Malorni, W.
AU - Rainaldi, G.
AU - Straface, E.
AU - Rivabene, R.
AU - Cossarizza, A.
AU - Capri, M.
AU - Monti, D.
AU - Franceschi, C.
PY - 1994
Y1 - 1994
N2 - 3-aminobenzamide (3-ABA) is an inhibitor of poly-ADP-ribose-polymerase, an enzyme involved in numerous subcellular processes including cell death. With the aim of contributing to clarify the mode of action of the drug, which is still poorly understood, its effects on cultured melanoma cells M14 have been assessed. In particular, an impairment of cell growth accompanied by the formation of long and numerous dendritic-like protrusions has been detected. This finding appears to be due to a specific effect of the drug on some cytoskeletal elements and could be associated with its differentiating capability. This finding, together with previous data from our group - Biochem. Biophys. Res. Commun., (1994) 199, 525-530 and 1250-1255 - suggests that cytoskeleton is an important target of 3-ABA.
AB - 3-aminobenzamide (3-ABA) is an inhibitor of poly-ADP-ribose-polymerase, an enzyme involved in numerous subcellular processes including cell death. With the aim of contributing to clarify the mode of action of the drug, which is still poorly understood, its effects on cultured melanoma cells M14 have been assessed. In particular, an impairment of cell growth accompanied by the formation of long and numerous dendritic-like protrusions has been detected. This finding appears to be due to a specific effect of the drug on some cytoskeletal elements and could be associated with its differentiating capability. This finding, together with previous data from our group - Biochem. Biophys. Res. Commun., (1994) 199, 525-530 and 1250-1255 - suggests that cytoskeleton is an important target of 3-ABA.
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U2 - 10.1006/bbrc.1994.2017
DO - 10.1006/bbrc.1994.2017
M3 - Article
C2 - 8048965
AN - SCOPUS:0028001413
VL - 202
SP - 915
EP - 922
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -