3-Aryl-N-aminoylsulfonylphenyl-1H-pyrazole-5-carboxamides: A new class of selective Rac inhibitors

Nicola Ferri, Sergio Kevin Bernini, Alberto Corsini, Francesca Clerici, Emanuela Erba, Stefano Stragliotto, Alessandro Contini

Research output: Contribution to journal › Article

17 Citations (Scopus)

Abstract

Through a computational approach, five new compounds with potent and selective Rac inhibitory activity were identified. In particular, compound 4 was shown to selectively inhibit Rac activity in a concentration-dependent manner by affecting the GEF-dependent GDP-GTP exchange. This compound was more potent than the original inhibitors previously identified.

Original languageEnglish
Pages (from-to)537-541
Number of pages5
JournalMedChemComm
Volume4
Issue number3
DOIs
Publication statusPublished - Mar 2013

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Guanosine Triphosphate
pyrazole-5-carboxamide

ASJC Scopus subject areas

  • Biochemistry
  • Pharmaceutical Science

Cite this

Ferri, N., Bernini, S. K., Corsini, A., Clerici, F., Erba, E., Stragliotto, S., & Contini, A. (2013). 3-Aryl-N-aminoylsulfonylphenyl-1H-pyrazole-5-carboxamides: A new class of selective Rac inhibitors. MedChemComm, 4(3), 537-541. https://doi.org/10.1039/c2md20328f

3-Aryl-N-aminoylsulfonylphenyl-1H-pyrazole-5-carboxamides : A new class of selective Rac inhibitors. / Ferri, Nicola; Bernini, Sergio Kevin; Corsini, Alberto; Clerici, Francesca; Erba, Emanuela; Stragliotto, Stefano; Contini, Alessandro.

In: MedChemComm, Vol. 4, No. 3, 03.2013, p. 537-541.

Research output: Contribution to journal › Article

Ferri, N, Bernini, SK, Corsini, A, Clerici, F, Erba, E, Stragliotto, S & Contini, A 2013, '3-Aryl-N-aminoylsulfonylphenyl-1H-pyrazole-5-carboxamides: A new class of selective Rac inhibitors', MedChemComm, vol. 4, no. 3, pp. 537-541. https://doi.org/10.1039/c2md20328f
Ferri N, Bernini SK, Corsini A, Clerici F, Erba E, Stragliotto S et al. 3-Aryl-N-aminoylsulfonylphenyl-1H-pyrazole-5-carboxamides: A new class of selective Rac inhibitors. MedChemComm. 2013 Mar;4(3):537-541. https://doi.org/10.1039/c2md20328f
Ferri, Nicola ; Bernini, Sergio Kevin ; Corsini, Alberto ; Clerici, Francesca ; Erba, Emanuela ; Stragliotto, Stefano ; Contini, Alessandro. / 3-Aryl-N-aminoylsulfonylphenyl-1H-pyrazole-5-carboxamides : A new class of selective Rac inhibitors. In: MedChemComm. 2013 ; Vol. 4, No. 3. pp. 537-541.
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