3-Aryl-N-aminoylsulfonylphenyl-1H-pyrazole-5-carboxamides: A new class of selective Rac inhibitors

Nicola Ferri, Sergio Kevin Bernini, Alberto Corsini, Francesca Clerici, Emanuela Erba, Stefano Stragliotto, Alessandro Contini

Research output: Contribution to journalArticle

Abstract

Through a computational approach, five new compounds with potent and selective Rac inhibitory activity were identified. In particular, compound 4 was shown to selectively inhibit Rac activity in a concentration-dependent manner by affecting the GEF-dependent GDP-GTP exchange. This compound was more potent than the original inhibitors previously identified.

Original languageEnglish
Pages (from-to)537-541
Number of pages5
JournalMedChemComm
Volume4
Issue number3
DOIs
Publication statusPublished - Mar 2013

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ASJC Scopus subject areas

  • Biochemistry
  • Pharmaceutical Science

Cite this

Ferri, N., Bernini, S. K., Corsini, A., Clerici, F., Erba, E., Stragliotto, S., & Contini, A. (2013). 3-Aryl-N-aminoylsulfonylphenyl-1H-pyrazole-5-carboxamides: A new class of selective Rac inhibitors. MedChemComm, 4(3), 537-541. https://doi.org/10.1039/c2md20328f