3-Aryl-N-aminoylsulfonylphenyl-1H-pyrazole-5-carboxamides: A new class of selective Rac inhibitors

Nicola Ferri; Sergio Kevin Bernini; Alberto Corsini; Francesca Clerici; Emanuela Erba; Stefano Stragliotto; Alessandro Contini

doi:10.1039/c2md20328f

3-Aryl-N-aminoylsulfonylphenyl-1H-pyrazole-5-carboxamides: A new class of selective Rac inhibitors

Nicola Ferri, Sergio Kevin Bernini, Alberto Corsini, Francesca Clerici, Emanuela Erba, Stefano Stragliotto, Alessandro Contini

IRCCS Multimedica

Research output: Contribution to journal › Article › peer-review

Abstract

Through a computational approach, five new compounds with potent and selective Rac inhibitory activity were identified. In particular, compound 4 was shown to selectively inhibit Rac activity in a concentration-dependent manner by affecting the GEF-dependent GDP-GTP exchange. This compound was more potent than the original inhibitors previously identified.

Original language	English
Pages (from-to)	537-541
Number of pages	5
Journal	MedChemComm
Volume	4
Issue number	3
DOIs	https://doi.org/10.1039/c2md20328f
Publication status	Published - Mar 2013

ASJC Scopus subject areas

Biochemistry
Pharmaceutical Science

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title = "3-Aryl-N-aminoylsulfonylphenyl-1H-pyrazole-5-carboxamides: A new class of selective Rac inhibitors",

abstract = "Through a computational approach, five new compounds with potent and selective Rac inhibitory activity were identified. In particular, compound 4 was shown to selectively inhibit Rac activity in a concentration-dependent manner by affecting the GEF-dependent GDP-GTP exchange. This compound was more potent than the original inhibitors previously identified.",

author = "Nicola Ferri and Bernini, {Sergio Kevin} and Alberto Corsini and Francesca Clerici and Emanuela Erba and Stefano Stragliotto and Alessandro Contini",

year = "2013",

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AU - Corsini, Alberto

AU - Clerici, Francesca

AU - Erba, Emanuela

AU - Stragliotto, Stefano

AU - Contini, Alessandro

PY - 2013/3

Y1 - 2013/3

N2 - Through a computational approach, five new compounds with potent and selective Rac inhibitory activity were identified. In particular, compound 4 was shown to selectively inhibit Rac activity in a concentration-dependent manner by affecting the GEF-dependent GDP-GTP exchange. This compound was more potent than the original inhibitors previously identified.

AB - Through a computational approach, five new compounds with potent and selective Rac inhibitory activity were identified. In particular, compound 4 was shown to selectively inhibit Rac activity in a concentration-dependent manner by affecting the GEF-dependent GDP-GTP exchange. This compound was more potent than the original inhibitors previously identified.

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3-Aryl-N-aminoylsulfonylphenyl-1H-pyrazole-5-carboxamides: A new class of selective Rac inhibitors

Abstract

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