Abstract
Through a computational approach, five new compounds with potent and selective Rac inhibitory activity were identified. In particular, compound 4 was shown to selectively inhibit Rac activity in a concentration-dependent manner by affecting the GEF-dependent GDP-GTP exchange. This compound was more potent than the original inhibitors previously identified.
Original language | English |
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Pages (from-to) | 537-541 |
Number of pages | 5 |
Journal | MedChemComm |
Volume | 4 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2013 |
ASJC Scopus subject areas
- Biochemistry
- Pharmaceutical Science