3′ creatine kinase (M-type) polymorphisms linked to myotonic dystrophy in Italian and Spanish populations

Massimo Gennarelli, Giuseppe Novelli, Ana Cobo, Montserrat Baiget, Bruno Dallapiccola

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Abstract

Linkage analysis and haplotype characterization for the allelic system detected at the 3′ creatine kinase muscle type (CKMM) locus were carried out in 59 myotonic dystrophy (DM) families from Italy and Spain. A maximum lod score (zmax) of 21.26 at a recombination frequency (θ) of 0.00 was found. No statistically significant linkage disequilibrium was observed between DM and the RFLPs examined. However, a substantial linkage disequilibrium was found between CKMM-TaqI and CKMM-NcoI sites in these two populations.

Original languageEnglish
Pages (from-to)654-656
Number of pages3
JournalHuman Genetics
Volume87
Issue number6
DOIs
Publication statusPublished - Oct 1991

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ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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