3-hydroxy-3-methylglutaryl coenzyme A reductase activity and low-density lipoprotein receptor expression in diffuse-type and intestinal-type human gastric cancer

Maria Gabrielle Caruso, Maria Notarnicola, Aldo Cavallini, Alfredo Di Leo

Research output: Contribution to journalArticle

Abstract

Background. Cancer cells require more cholesterol than normal cells. This requirement may be satisfied by higher hydroxy-methyl-glutaryl coenzyme A reductase activity or low-density lipoprotein receptor expression or both. We investigated hydroxy-methyl-glutaryl coenzyme A reductase activity and low-density lipoprotein receptor expression in samples of gastric carcinoma and normal mucosa obtained from 30 patients. The samples of gastric carcinoma were divided into two categories according to Lauren's classification: diffuse-type and intestinal-type. Methods. Hydroxy-methyl-glutaryl coenzyme A reductase activity was measured by radiometric assay and low-density lipoprotein receptor expression was measured by enzyme-linked immunosorbent assay. Results. Hydroxy-methyl-glutaryl-coenzyme A reductase activity was significantly higher in neoplastic tissue than in normal mucosa, both in diffuse-type and intestinal-type gastric cancer. Lowdensity lipoprotein receptor levels were significantly lower in neoplastic tissue than in normal mucosa of diffuse-type gastric cancer, whereas no significant difference was present between neoplastic tissue and normal mucosa in intestinal-type gastric cancer. Hydroxy-methyl-glutaryl-coenzyme A reductase activity did not differ between intestinal-type and diffusetype neoplastic samples, while low-density lipoprotein receptor levels were significantly higher in intestinaltype than in diffuse-type gastric cancer tissue. Conclusions. These findings show different behavior of cholesterol metabolism in the two types of gastric carcinoma and, therefore, suggest that different therapeutic strategies should be adopted.

Original languageEnglish
Pages (from-to)504-508
Number of pages5
JournalJournal of Gastroenterology
Volume37
Issue number7
DOIs
Publication statusPublished - 2002

    Fingerprint

Keywords

  • Diffuse-type GC
  • HMGCoAR
  • Intestinal-type GC
  • LDLR

ASJC Scopus subject areas

  • Gastroenterology

Cite this