Urinary excretion of creatinine (CRu) and of 3-methylhistidine when a subject is on a meat free diet, are indices of muscle mass and muscle protein catabolism, respectively. 3MHIu/CRu is recognized as a useful non invasive technique for assessing myofibrillar protein breakdown/muscle mass ratio. Our study aimed to measure CRu, 3MHIu and calculated 3MHIu/CRu ratio in patients with tetraplegia (T) in order to better understanding protein metabolism in muscle tissue. Five male patients with tetraplegia 32.2 ± 16.4 years old, 38 ± 12 days after the accident were investigated. As control group (C) we considered two groups of healthy subjects: one group with normal nutritional state (NNS) and the other with body weight as % ideal body weight similar to that registered in T. For three consecutive days all the subjects were on isocaloric meat free diet. Contemporary, 24 hrs urine was collected to measure CRu, 3MHIu and then 3MHIu/CRu. Our investigation showed in patients T lower CRu, 3MHIu, 3MHIu/CRu than in NNS group, while CRu/kg, 3MHIu/kg body weight and 3MHIu/CRu were lower than in group I. Authors conclude that patients T are characterized by reduced muscle protein metabolism probahly due to denervation status. As practical results, it exists the possibility of monitoring the effects of nutritional and/or rehabilitation therapy on muscle protein metabolism in patients T.
|Translated title of the contribution||3-Methylhistidine as an index of muscle protein catabolism in patients with tetraplegia|
|Number of pages||5|
|Publication status||Published - 1995|
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