TY - JOUR
T1 - 30 days and midterm outcomes of patients undergoing percutaneous replacement of aortic valve according to their renal function
T2 - A multicenter study
AU - D'Ascenzo, Fabrizio
AU - Moretti, Claudio
AU - Salizzoni, Stefano
AU - Bollati, Mario
AU - D'Amico, Maurizio
AU - Ballocca, Flavia
AU - Giordana, Francesca
AU - Barbanti, Marco
AU - Ussia, Gian Paolo
AU - Brambilla, Nedy
AU - Bedogni, Francesco
AU - Biondi Zoccai, Giuseppe
AU - Tamburino, Corrado
AU - Gaita, Fiorenzo
AU - Sheiban, Imad
PY - 2013/8/20
Y1 - 2013/8/20
N2 - Introduction: Chronic kidney disease (CKD) constitutes a predictor of adverse events for surgical aortic valve replacement. In patients undergoing TAVI no study was performed to evaluate outcomes according to renal clearance, which represents the most accurate instrument to assess kidney function. Methods: From January 2007 to December 2011 all TAVI patients of our institutions were prospectively divided into 3 cohorts. Preserved renal function those with clearance more or equal to 60 ml/min/1.73 m2, moderate CKD those between 30 and 60, and severe CKD those between 15 and 30. Patients with a clearance less than 15 or in dyalysis were excluded. All outcomes were adjudicated according to VARC criterion. Results: 72 patients with preserved renal function, 219 with moderate and 73 with severe CKD were included; those in the latter group were older and with lower ejection fraction. At 30 days, severe CKD was associated with a trend toward a higher risk of major events than preserved and moderate CKD: cardiovascular death (2.8% vs 6.7% vs 9%; p = 0.256) life threatening bleedings (10% vs 10% vs 16%; p = 0.384), major stroke (1.4% vs 2.3% vs 4.1%; p = 0.763). At a medium follow-up of 540 ± 250 days, cardiovascular death incidence was higher in patients with severe CKD (7% vs 8 vs 19%; p <0.0001), however this difference was not consistently significant after multivariable adjustment (p = 0.300). Overall, 2% of patients developed kidney failure, whereas 47.1% of patients with severe CKD improved to moderate renal impairment. Conclusions: Patients with severe chronic renal disease presented higher risk of adverse events, mainly driven by increased hazard of bleedings. TAVI procedures could offer kidney functional improvement in an important subset of patients.
AB - Introduction: Chronic kidney disease (CKD) constitutes a predictor of adverse events for surgical aortic valve replacement. In patients undergoing TAVI no study was performed to evaluate outcomes according to renal clearance, which represents the most accurate instrument to assess kidney function. Methods: From January 2007 to December 2011 all TAVI patients of our institutions were prospectively divided into 3 cohorts. Preserved renal function those with clearance more or equal to 60 ml/min/1.73 m2, moderate CKD those between 30 and 60, and severe CKD those between 15 and 30. Patients with a clearance less than 15 or in dyalysis were excluded. All outcomes were adjudicated according to VARC criterion. Results: 72 patients with preserved renal function, 219 with moderate and 73 with severe CKD were included; those in the latter group were older and with lower ejection fraction. At 30 days, severe CKD was associated with a trend toward a higher risk of major events than preserved and moderate CKD: cardiovascular death (2.8% vs 6.7% vs 9%; p = 0.256) life threatening bleedings (10% vs 10% vs 16%; p = 0.384), major stroke (1.4% vs 2.3% vs 4.1%; p = 0.763). At a medium follow-up of 540 ± 250 days, cardiovascular death incidence was higher in patients with severe CKD (7% vs 8 vs 19%; p <0.0001), however this difference was not consistently significant after multivariable adjustment (p = 0.300). Overall, 2% of patients developed kidney failure, whereas 47.1% of patients with severe CKD improved to moderate renal impairment. Conclusions: Patients with severe chronic renal disease presented higher risk of adverse events, mainly driven by increased hazard of bleedings. TAVI procedures could offer kidney functional improvement in an important subset of patients.
KW - Bleedings
KW - Improvement in renal clearance
KW - Renal function
KW - Stroke
KW - TAVI
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U2 - 10.1016/j.ijcard.2012.04.161
DO - 10.1016/j.ijcard.2012.04.161
M3 - Article
C2 - 22726400
AN - SCOPUS:84881481380
VL - 167
SP - 1514
EP - 1518
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 4
ER -