TY - JOUR
T1 - 300-Hz subthalamic oscillations in Parkinson's disease
AU - Foffani, G.
AU - Priori, Alberto
AU - Egidi, M.
AU - Rampini, P.
AU - Tamma, F.
AU - Caputo, E.
AU - Moxon, K. A.
AU - Cerutti, S.
AU - Barbieri, S.
PY - 2003/10
Y1 - 2003/10
N2 - Despite several studies and models, much remains unclear about how the human basal ganglia operate. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for complicated Parkinson's disease, but how DBS acts also remains unknown. The clinical benefit of DBS at frequencies >100 Hz suggests the possible importance of neural rhythms operating at frequencies higher than the range normally considered for basal ganglia processing (100 Hz operate in the human STN. While recording local field potentials from the STN of nine patients with Parkinson's disease through DBS electrodes, we found a dopamine- and movement-dependent 300-Hz rhythm. At rest, and in the absence of dopaminergic medication, in most cases (eight out of 11 nuclei) the 100-1000 Hz band showed no consistent rhythm. Levodopa administration elicited (or markedly increased) a 300-Hz rhythm at rest [(mean ± SD) central frequency: 319 ± 33 Hz; bandwidth: 72 ± 21 Hz; power increase (after medication - before medication)/before medication: 1.30 ± 1.25; n = 11, P = 0.00098]. The 300-Hz rhythm was also increased by apomorphine, but not by orphenadrine. The 300-Hz rhythm was modulated by voluntary movement. Before levodopa administration, movement-related power increase in the 300-Hz rhythm was variably present in different subjects, whereas after levodopa it became a robust phenomenon [before 0.014 ± 0.014 arbitrary units (AU), after 0. 178 ± 0.339 AU; n = 8, P = 0.0078]. The dopamine-dependent 300-Hz rhythm probably reflects a bistable compound nuclear activity and supports high-resolution information processing in the basal ganglia circuit. An absent 300-Hz subthalamic rhythm could be a pathophysiological clue in Parkinson's disease. The 300-Hz rhythm also provides the rationale for an excitatory - and not only inhibitory - interpretation of DBS mechanism of action in humans.
AB - Despite several studies and models, much remains unclear about how the human basal ganglia operate. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for complicated Parkinson's disease, but how DBS acts also remains unknown. The clinical benefit of DBS at frequencies >100 Hz suggests the possible importance of neural rhythms operating at frequencies higher than the range normally considered for basal ganglia processing (100 Hz operate in the human STN. While recording local field potentials from the STN of nine patients with Parkinson's disease through DBS electrodes, we found a dopamine- and movement-dependent 300-Hz rhythm. At rest, and in the absence of dopaminergic medication, in most cases (eight out of 11 nuclei) the 100-1000 Hz band showed no consistent rhythm. Levodopa administration elicited (or markedly increased) a 300-Hz rhythm at rest [(mean ± SD) central frequency: 319 ± 33 Hz; bandwidth: 72 ± 21 Hz; power increase (after medication - before medication)/before medication: 1.30 ± 1.25; n = 11, P = 0.00098]. The 300-Hz rhythm was also increased by apomorphine, but not by orphenadrine. The 300-Hz rhythm was modulated by voluntary movement. Before levodopa administration, movement-related power increase in the 300-Hz rhythm was variably present in different subjects, whereas after levodopa it became a robust phenomenon [before 0.014 ± 0.014 arbitrary units (AU), after 0. 178 ± 0.339 AU; n = 8, P = 0.0078]. The dopamine-dependent 300-Hz rhythm probably reflects a bistable compound nuclear activity and supports high-resolution information processing in the basal ganglia circuit. An absent 300-Hz subthalamic rhythm could be a pathophysiological clue in Parkinson's disease. The 300-Hz rhythm also provides the rationale for an excitatory - and not only inhibitory - interpretation of DBS mechanism of action in humans.
KW - Deep brain stimulation
KW - Event-related synchronization
KW - High frequency
KW - Levodopa
KW - Subthalamus
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U2 - 10.1093/brain/awg229
DO - 10.1093/brain/awg229
M3 - Article
C2 - 12937087
AN - SCOPUS:0242273111
VL - 126
SP - 2153
EP - 2163
JO - Brain
JF - Brain
SN - 0006-8950
IS - 10
ER -