High plasma fibrinogen levels are considered a major risk factor for arterial thrombotic diseases. Whether fibrinogen genotype is associated with the risk of ischémie heart disease has not been well established so far. We focused our study on the Bell polymorphism in the -chain of the fibrinogen gene: the polymerase chain reaction was followed by the use of the Bell restriction enzyme to detect alleles Bl and B2. Preliminary analyses were performed on one hundred twenty four patients with AMI and the same number of controls (matched for sex, age, hospital and time of admission), aged 44-74, recruited across Italy from the GISSI-2 centres. The genotype distributions were in Hardy-Weinberg equilibrium. There was no difference in allele frequencies between cases and controls: the Bl and B2 frequencies were 0.70 and 0.30 in cases with AMI, and 0.78 and 0.22 in controls (p=n.s.). There was no significant interaction between Bell genotype and the effect of smoking on AMI risk. We tested also the effect of the Bell genotype on fibrinogen levels both in cases and in controls: the mean levels in B1B1 vs B1B2 vs B2B2 subjects in groups were significantly different. These data provide evidence for a role of this genetic polymorphism in the variability of fibrinogen levels, while its relation with the risk of AMI deserves further evaluation.
|Number of pages||1|
|Issue number||SUPPL. 1|
|Publication status||Published - 1996|
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