Abstract
Roundup is a postemergence herbicide acting on the synthesis of amino acids and other important endogenous chemicals in plants. Roundup is commonly used in agriculture, forestry, and nurseries for the control or destruction of most herbaceous plants. The present study shows that Roundup is able to induce a dose-dependent formation of DNA adducts in the kidneys and liver of mice. The levels of Roundup-related DNA adducts observed in mouse kidneys and liver at the highest dose of herbicide tested (600 mg/kg) were 3.0 ± 0.1 (SE) and 1.7 ± 0.1 (SE) adducts/108 nucleotides, respectively. The Roundup DNA adducts were not related to the active ingredient, the isopropylammonium salt of glyphosate, but to another, unknown component of the herbicide mixture. Additional experiments are needed to identify the chemical specie(s) of Roundup mixture involved in DNA adducts formation. Findings of this study may help to protect agricultural workers from health hazards and provide a basis for risk assessment.
| Original language | English |
|---|---|
| Pages (from-to) | 55-59 |
| Number of pages | 5 |
| Journal | Environmental and Molecular Mutagenesis |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1998 |
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Keywords
- P-postlabeling
- DNA adducts
- Herbicide
- Roundup
ASJC Scopus subject areas
- Environmental Science(all)
- Environmental Chemistry
- Genetics
- Genetics(clinical)
- Toxicology
- Health, Toxicology and Mutagenesis
Cite this
32P-Postlabeling detection of DNA adducts in mice treated with the herbicide Roundup. / Peluso, Marco; Munnia, Armelle; Bolognesi, Claudia; Parodi, Silvio.
In: Environmental and Molecular Mutagenesis, Vol. 31, No. 1, 1998, p. 55-59.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 32P-Postlabeling detection of DNA adducts in mice treated with the herbicide Roundup
AU - Peluso, Marco
AU - Munnia, Armelle
AU - Bolognesi, Claudia
AU - Parodi, Silvio
PY - 1998
Y1 - 1998
N2 - Roundup is a postemergence herbicide acting on the synthesis of amino acids and other important endogenous chemicals in plants. Roundup is commonly used in agriculture, forestry, and nurseries for the control or destruction of most herbaceous plants. The present study shows that Roundup is able to induce a dose-dependent formation of DNA adducts in the kidneys and liver of mice. The levels of Roundup-related DNA adducts observed in mouse kidneys and liver at the highest dose of herbicide tested (600 mg/kg) were 3.0 ± 0.1 (SE) and 1.7 ± 0.1 (SE) adducts/108 nucleotides, respectively. The Roundup DNA adducts were not related to the active ingredient, the isopropylammonium salt of glyphosate, but to another, unknown component of the herbicide mixture. Additional experiments are needed to identify the chemical specie(s) of Roundup mixture involved in DNA adducts formation. Findings of this study may help to protect agricultural workers from health hazards and provide a basis for risk assessment.
AB - Roundup is a postemergence herbicide acting on the synthesis of amino acids and other important endogenous chemicals in plants. Roundup is commonly used in agriculture, forestry, and nurseries for the control or destruction of most herbaceous plants. The present study shows that Roundup is able to induce a dose-dependent formation of DNA adducts in the kidneys and liver of mice. The levels of Roundup-related DNA adducts observed in mouse kidneys and liver at the highest dose of herbicide tested (600 mg/kg) were 3.0 ± 0.1 (SE) and 1.7 ± 0.1 (SE) adducts/108 nucleotides, respectively. The Roundup DNA adducts were not related to the active ingredient, the isopropylammonium salt of glyphosate, but to another, unknown component of the herbicide mixture. Additional experiments are needed to identify the chemical specie(s) of Roundup mixture involved in DNA adducts formation. Findings of this study may help to protect agricultural workers from health hazards and provide a basis for risk assessment.
KW - P-postlabeling
KW - DNA adducts
KW - Herbicide
KW - Roundup
UR - http://www.scopus.com/inward/record.url?scp=0031594478&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031594478&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1098-2280(1998)31:1<55::AID-EM8>3.0.CO;2-A
DO - 10.1002/(SICI)1098-2280(1998)31:1<55::AID-EM8>3.0.CO;2-A
M3 - Article
C2 - 9464316
AN - SCOPUS:0031594478
VL - 31
SP - 55
EP - 59
JO - Environmental Mutagenesis
JF - Environmental Mutagenesis
SN - 0893-6692
IS - 1
ER -