TY - JOUR
T1 - -344C/T Variant in the Promoter of the Aldosterone Synthase Gene (CYP11B2) Is Associated With Metabolic Syndrome in Men
AU - Russo, Paola
AU - Lauria, Fabio
AU - Loguercio, Maria
AU - Barba, Gianvincenzo
AU - Arnout, Josef
AU - Cappuccio, Francesco P.
AU - de Lorgeril, Michel
AU - Donati, Maria B.
AU - Iacoviello, Licia
AU - Krogh, Vittorio
AU - van Dongen, Martien
AU - Siani, Alfonso
PY - 2007/2
Y1 - 2007/2
N2 - Background: The -344C/T variant in the promoter of the aldosterone synthase gene (CYP11B2) has been associated with hypertension and may influence glucose homeostasis and body mass in humans. We assessed the association between this genetic variant and metabolic syndrome in a large sample of European population. Methods: Eight hundred two male/female couples, recruited in the framework of the IMMIDIET study, a survey on cardiovascular risk in Italy, UK, and Belgium, had standardized measurements of body mass index, waist circumference, blood pressure (BP), serum total and HDL-cholesterol, triglycerides, and glucose and were genotyped for the -344C/T variant of CYP11B2. Metabolic syndrome was defined according to the International Diabetes Federation criteria. Results: The prevalence of the metabolic syndrome was 23.9% in men and 14.0% in women. The C allele of the variant was associated with metabolic syndrome in men (P = .002) but not in women. At logistic regression analysis, the odds ratio of metabolic syndrome increased progressively with the number of copies of the C allele (CT: 1.54, 95% CI from 1.01 to 2.35; CC: 2.25, 95% CI from 1.38 to 3.66) as compared with the TT homozygotes, taken as reference genotype. Conclusions: The C allele of -344C/T variant of CYP11B2 increases susceptibility to metabolic syndrome in European men, but not in women, suggesting a pleiotropic role for this gene in modulating cardiovascular risk.
AB - Background: The -344C/T variant in the promoter of the aldosterone synthase gene (CYP11B2) has been associated with hypertension and may influence glucose homeostasis and body mass in humans. We assessed the association between this genetic variant and metabolic syndrome in a large sample of European population. Methods: Eight hundred two male/female couples, recruited in the framework of the IMMIDIET study, a survey on cardiovascular risk in Italy, UK, and Belgium, had standardized measurements of body mass index, waist circumference, blood pressure (BP), serum total and HDL-cholesterol, triglycerides, and glucose and were genotyped for the -344C/T variant of CYP11B2. Metabolic syndrome was defined according to the International Diabetes Federation criteria. Results: The prevalence of the metabolic syndrome was 23.9% in men and 14.0% in women. The C allele of the variant was associated with metabolic syndrome in men (P = .002) but not in women. At logistic regression analysis, the odds ratio of metabolic syndrome increased progressively with the number of copies of the C allele (CT: 1.54, 95% CI from 1.01 to 2.35; CC: 2.25, 95% CI from 1.38 to 3.66) as compared with the TT homozygotes, taken as reference genotype. Conclusions: The C allele of -344C/T variant of CYP11B2 increases susceptibility to metabolic syndrome in European men, but not in women, suggesting a pleiotropic role for this gene in modulating cardiovascular risk.
KW - Aldosterone synthase
KW - CYP11B2
KW - metabolic syndrome
KW - polymorphism
KW - population study
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U2 - 10.1016/j.amjhyper.2006.07.012
DO - 10.1016/j.amjhyper.2006.07.012
M3 - Article
C2 - 17261471
AN - SCOPUS:33846447794
VL - 20
SP - 218
EP - 222
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 2
ER -