3,5-Dicaffeoyl-4-malonylquinic acid reduced oxidative stress and inflammation in a experimental model of inflammatory bowel disease

Rosanna Di Paola, Emanuela Esposito, Emanuela Mazzon, Rocco Caminiti, Roberto Dal Toso, Giovanna Pressi, Salvatore Cozzocrea

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Aim: The aim of the present study was to examine the effects of 3,5-dicaffeoyl-4-malonylquinic acid (CA1), extract from Centella Asiatica, in rats subjected to experimental colitis. Results: Colitis was induced in rats by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS). CA1 was administered daily orally (0.2 or 2 mg/kg). Four days after DNBS administration, treatment with CA1 significantly reduced the appearance of diarrhoea and the loss of body weight. This was associated with a significant reduction in colonic MPO activity. CA1 also reduced NF-κB activation, the pro-inflammatory cytokines release, the appearance of I-NOS, nitrotyrosine, PARP and proMMP-9 and-2 activity in the colon and reduced the up-regulation of ICAM-1 and the expression of P-Selectin. Conclusions: The results of this study suggested that administration of CA1 may be beneficial for treatment of inflammatory bowel disease.

Original languageEnglish
Pages (from-to)74-89
Number of pages16
JournalFree Radical Research
Volume44
Issue number1
DOIs
Publication statusPublished - 2010

Fingerprint

Dinitrobenzenes
Oxidative stress
Sulfonic Acids
Colitis
Inflammatory Bowel Diseases
Rats
Oxidative Stress
Theoretical Models
Inflammation
P-Selectin
Intercellular Adhesion Molecule-1
Diarrhea
Colon
Up-Regulation
Thermodynamic properties
Chemical activation
Body Weight
Cytokines
3,5-dicaffeoyl-4-malonylquinic acid

Keywords

  • 3,5-Dicaffeoyl-4-malonylquinic acid
  • B
  • Colitis
  • Neutrophil infi ltration
  • NF-κ

ASJC Scopus subject areas

  • Biochemistry

Cite this

3,5-Dicaffeoyl-4-malonylquinic acid reduced oxidative stress and inflammation in a experimental model of inflammatory bowel disease. / Di Paola, Rosanna; Esposito, Emanuela; Mazzon, Emanuela; Caminiti, Rocco; Toso, Roberto Dal; Pressi, Giovanna; Cozzocrea, Salvatore.

In: Free Radical Research, Vol. 44, No. 1, 2010, p. 74-89.

Research output: Contribution to journalArticle

Di Paola, Rosanna ; Esposito, Emanuela ; Mazzon, Emanuela ; Caminiti, Rocco ; Toso, Roberto Dal ; Pressi, Giovanna ; Cozzocrea, Salvatore. / 3,5-Dicaffeoyl-4-malonylquinic acid reduced oxidative stress and inflammation in a experimental model of inflammatory bowel disease. In: Free Radical Research. 2010 ; Vol. 44, No. 1. pp. 74-89.
@article{2e7b35ae68234978a5321fbc9d105e2b,
title = "3,5-Dicaffeoyl-4-malonylquinic acid reduced oxidative stress and inflammation in a experimental model of inflammatory bowel disease",
abstract = "Aim: The aim of the present study was to examine the effects of 3,5-dicaffeoyl-4-malonylquinic acid (CA1), extract from Centella Asiatica, in rats subjected to experimental colitis. Results: Colitis was induced in rats by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS). CA1 was administered daily orally (0.2 or 2 mg/kg). Four days after DNBS administration, treatment with CA1 significantly reduced the appearance of diarrhoea and the loss of body weight. This was associated with a significant reduction in colonic MPO activity. CA1 also reduced NF-κB activation, the pro-inflammatory cytokines release, the appearance of I-NOS, nitrotyrosine, PARP and proMMP-9 and-2 activity in the colon and reduced the up-regulation of ICAM-1 and the expression of P-Selectin. Conclusions: The results of this study suggested that administration of CA1 may be beneficial for treatment of inflammatory bowel disease.",
keywords = "3,5-Dicaffeoyl-4-malonylquinic acid, B, Colitis, Neutrophil infi ltration, NF-κ",
author = "{Di Paola}, Rosanna and Emanuela Esposito and Emanuela Mazzon and Rocco Caminiti and Toso, {Roberto Dal} and Giovanna Pressi and Salvatore Cozzocrea",
year = "2010",
doi = "10.3109/10715760903300709",
language = "English",
volume = "44",
pages = "74--89",
journal = "Free Radical Research",
issn = "1071-5762",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - 3,5-Dicaffeoyl-4-malonylquinic acid reduced oxidative stress and inflammation in a experimental model of inflammatory bowel disease

AU - Di Paola, Rosanna

AU - Esposito, Emanuela

AU - Mazzon, Emanuela

AU - Caminiti, Rocco

AU - Toso, Roberto Dal

AU - Pressi, Giovanna

AU - Cozzocrea, Salvatore

PY - 2010

Y1 - 2010

N2 - Aim: The aim of the present study was to examine the effects of 3,5-dicaffeoyl-4-malonylquinic acid (CA1), extract from Centella Asiatica, in rats subjected to experimental colitis. Results: Colitis was induced in rats by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS). CA1 was administered daily orally (0.2 or 2 mg/kg). Four days after DNBS administration, treatment with CA1 significantly reduced the appearance of diarrhoea and the loss of body weight. This was associated with a significant reduction in colonic MPO activity. CA1 also reduced NF-κB activation, the pro-inflammatory cytokines release, the appearance of I-NOS, nitrotyrosine, PARP and proMMP-9 and-2 activity in the colon and reduced the up-regulation of ICAM-1 and the expression of P-Selectin. Conclusions: The results of this study suggested that administration of CA1 may be beneficial for treatment of inflammatory bowel disease.

AB - Aim: The aim of the present study was to examine the effects of 3,5-dicaffeoyl-4-malonylquinic acid (CA1), extract from Centella Asiatica, in rats subjected to experimental colitis. Results: Colitis was induced in rats by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS). CA1 was administered daily orally (0.2 or 2 mg/kg). Four days after DNBS administration, treatment with CA1 significantly reduced the appearance of diarrhoea and the loss of body weight. This was associated with a significant reduction in colonic MPO activity. CA1 also reduced NF-κB activation, the pro-inflammatory cytokines release, the appearance of I-NOS, nitrotyrosine, PARP and proMMP-9 and-2 activity in the colon and reduced the up-regulation of ICAM-1 and the expression of P-Selectin. Conclusions: The results of this study suggested that administration of CA1 may be beneficial for treatment of inflammatory bowel disease.

KW - 3,5-Dicaffeoyl-4-malonylquinic acid

KW - B

KW - Colitis

KW - Neutrophil infi ltration

KW - NF-κ

UR - http://www.scopus.com/inward/record.url?scp=71649104469&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71649104469&partnerID=8YFLogxK

U2 - 10.3109/10715760903300709

DO - 10.3109/10715760903300709

M3 - Article

C2 - 19886745

AN - SCOPUS:71649104469

VL - 44

SP - 74

EP - 89

JO - Free Radical Research

JF - Free Radical Research

SN - 1071-5762

IS - 1

ER -