3,5-Dicaffeoyl-4-malonylquinic acid reduced oxidative stress and inflammation in a experimental model of inflammatory bowel disease

Rosanna Di Paola, Emanuela Esposito, Emanuela Mazzon, Rocco Caminiti, Roberto Dal Toso, Giovanna Pressi, Salvatore Cozzocrea

Research output: Contribution to journalArticle

Abstract

Aim: The aim of the present study was to examine the effects of 3,5-dicaffeoyl-4-malonylquinic acid (CA1), extract from Centella Asiatica, in rats subjected to experimental colitis. Results: Colitis was induced in rats by intracolonic instillation of dinitrobenzene sulphonic acid (DNBS). CA1 was administered daily orally (0.2 or 2 mg/kg). Four days after DNBS administration, treatment with CA1 significantly reduced the appearance of diarrhoea and the loss of body weight. This was associated with a significant reduction in colonic MPO activity. CA1 also reduced NF-κB activation, the pro-inflammatory cytokines release, the appearance of I-NOS, nitrotyrosine, PARP and proMMP-9 and-2 activity in the colon and reduced the up-regulation of ICAM-1 and the expression of P-Selectin. Conclusions: The results of this study suggested that administration of CA1 may be beneficial for treatment of inflammatory bowel disease.

Original languageEnglish
Pages (from-to)74-89
Number of pages16
JournalFree Radical Research
Volume44
Issue number1
DOIs
Publication statusPublished - 2010

Keywords

  • 3,5-Dicaffeoyl-4-malonylquinic acid
  • B
  • Colitis
  • Neutrophil infi ltration
  • NF-κ

ASJC Scopus subject areas

  • Biochemistry

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