The incidence of epilepsy associated with primary brain tumors is related to localization, size, hystology, etc. Slow growing gliomas are the most epileptogenic lesions and there is a direct correlation between the chronicity of growth of the tumor and the incidence of epilepsy. We studied 110 consecutive patients affected by supratentorial gliomas in order to evaluate the incidence of epilepsy at presentation and in the course of the disease (recurrent and late onset epilepsy) and its relation with histology, location of the lesion and anticonvulsant treatment. The diagnosis was glioblastoma in 45 patients, anaplastic astrocytoma in 33 and astrocytoma low grade in 32. The mean age of patients was 51.4 years. Mean follow-up was 29.3 months. Epilepsy at the onset was present in 43.7% of patients affected by malignant glioma (anaplastic astrocytoma and glioblastoma multiforme) and in 84% of patients affected by low grade astrocytoma. The incidence of "recurrent" seizures (subsequent seizures in patients with epilepsy at the onset) was 48% in patients with anaplastic astrocytoma and 51% in patients with low grade astrocytoma. The incidence of late onset seizures (subsequent seizures in patients without epilepsy at the onset) was 17% in patients with anaplastic astrocytoma and 20% in patients with low grade astrocytoma. The incidence of adverse effects of anticonvulsant treatment was 21%. The low incidence of late onset seizures in patients affected by malignant glioma and the frequency of adverse effects of antiepilectic drugs confirm that long-term prophilactic treatment should be omitted in patients who are free of seizure at the onset.
|Number of pages||1|
|Journal||Italian Journal of Neurological Sciences|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Clinical Neurology