38. Serum total radical-trapping antioxidant parameter (TRAP) and thrombosis in diabetes mellitus

A. Ceriello, N. Bortolotti, A. Crescentini, R. Giacomello, G. Stel, C. Taboga, L. Tonutti, E. Motz, S. Lizzio, A. Russo

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Abstract

The existence of an oxidative stress in diabetes mellitus is still debated, as well as its possible contribution to the activation of thrombosis. The total radical-trapping antioxidant parameter (TRAP) has very recently been proposed as a tool to explore the antioxidant power of a serum sample. TRAP may be either directly measured by HPLC method (TRAPm) or calculated (TRAPc) by a mathematical formula taking into account the serum levels of four natural anti-oxidants: SH groups (SH), uric acid (U), Vit. E (E) and Vit. C (C). The difference between the two values is due to antioxidants which can not be directly measured. In this study we evaluated in 46 NIDDM patients and in 47 normal controls, all non-smokers, matched for age (58.2Ü.5 vs 55.1±1.3 years, M±SE), sex (27M and 19F vs 30M and 17F) and diet habit, TRAPm, TRAPc, SH, U, E and C, as well as the markers of thrombosis fibrinogen (F), prothrombin fragments 1+2 (Fl+2) and D-dimer (D-D). TRAPm (677.Ü15.8 vs 950.2116.0 μmol/1, p

Original languageEnglish
Pages (from-to)12
Number of pages1
JournalFibrinolysis
Volume10
Issue numberSUPPL. 1
Publication statusPublished - 1996

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ASJC Scopus subject areas

  • Hematology

Cite this

Ceriello, A., Bortolotti, N., Crescentini, A., Giacomello, R., Stel, G., Taboga, C., Tonutti, L., Motz, E., Lizzio, S., & Russo, A. (1996). 38. Serum total radical-trapping antioxidant parameter (TRAP) and thrombosis in diabetes mellitus. Fibrinolysis, 10(SUPPL. 1), 12.