TY - JOUR
T1 - 3D Graphene Scaffolds for Skeletal Muscle Regeneration
T2 - Future Perspectives
AU - Palmieri, Valentina
AU - Sciandra, Francesca
AU - Bozzi, Manuela
AU - De Spirito, Marco
AU - Papi, Massimiliano
N1 - Funding Information:
The research leading to these results has received funding from AIRC under IG 2019 – ID. 23124 project – P.I. MP. Università Cattolica del Sacro Cuore contributed to the funding of this research project and its publication.
Funding Information:
Funding. The research leading to these results has received funding from AIRC under IG 2019 ? ID. 23124 project ? P.I. MP. Universit? Cattolica del Sacro Cuore contributed to the funding of this research project and its publication.
Publisher Copyright:
© Copyright © 2020 Palmieri, Sciandra, Bozzi, De Spirito and Papi.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/5/5
Y1 - 2020/5/5
N2 - Although skeletal muscle can regenerate after injury, in chronic damages or in traumatic injuries its endogenous self-regeneration is impaired. Consequently, tissue engineering approaches are promising tools for improving skeletal muscle cells proliferation and engraftment. In the last decade, graphene and its derivates are being explored as novel biomaterials for scaffolds production for skeletal muscle repair. This review describes 3D graphene-based materials that are currently used to generate complex structures able not only to guide cell alignment and fusion but also to stimulate muscle contraction thanks to their electrical conductivity. Graphene is an allotrope of carbon that has indeed unique mechanical, electrical and surface properties and has been functionalized to interact with a wide range of synthetic and natural polymers resembling native musculoskeletal tissue. More importantly, graphene can stimulate stem cell differentiation and has been studied for cardiac, neuronal, bone, skin, adipose, and cartilage tissue regeneration. Here we recapitulate recent findings on 3D scaffolds for skeletal muscle repairing and give some hints for future research in multifunctional graphene implants.
AB - Although skeletal muscle can regenerate after injury, in chronic damages or in traumatic injuries its endogenous self-regeneration is impaired. Consequently, tissue engineering approaches are promising tools for improving skeletal muscle cells proliferation and engraftment. In the last decade, graphene and its derivates are being explored as novel biomaterials for scaffolds production for skeletal muscle repair. This review describes 3D graphene-based materials that are currently used to generate complex structures able not only to guide cell alignment and fusion but also to stimulate muscle contraction thanks to their electrical conductivity. Graphene is an allotrope of carbon that has indeed unique mechanical, electrical and surface properties and has been functionalized to interact with a wide range of synthetic and natural polymers resembling native musculoskeletal tissue. More importantly, graphene can stimulate stem cell differentiation and has been studied for cardiac, neuronal, bone, skin, adipose, and cartilage tissue regeneration. Here we recapitulate recent findings on 3D scaffolds for skeletal muscle repairing and give some hints for future research in multifunctional graphene implants.
KW - graphene
KW - implants
KW - scaffold
KW - skeletal muscle
KW - tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85084934406&partnerID=8YFLogxK
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U2 - 10.3389/fbioe.2020.00383
DO - 10.3389/fbioe.2020.00383
M3 - Review article
AN - SCOPUS:85084934406
VL - 8
JO - Frontiers in Bioengineering and Biotechnology
JF - Frontiers in Bioengineering and Biotechnology
SN - 2296-4185
M1 - 383
ER -