The distribution of glutamatergic N-methyl-D-aspartate (NMDA) receptors in the rat brain was investigated by tissue section autoradiography using the new radiolabeled, high affinity competitive antagonist, [3H]CGP 39653 (D,L-(E)-2-amino-4-propyl-5-phosphono-3-pentanoic acid) as the ligand. The results obtained in the young animal resembled those reported previously using [3H]CPP (3-[(±)-2-carboxypiperazin-4-yl] propyl-1-phosphoric acid). During aging, however, the new ligand revealed a decreased binding occurring not only in the thalamus and striatum but also in the hippocampus, a brain area that plays a key role in learning and memory, where CPP studies had not revealed significant changes. In the same area parallel decreases were observed also for the other class of ionotropic glutamatergic receptors, recognized by AMPA (a-amino-3-hidroxy-5-methyl-4-isoxazole propionic acid). The possible relevance of these results in the physiology and pathology of brain aging is discussed.
|Number of pages||9|
|Journal||Neuroscience Research Communications|
|Publication status||Published - 1993|
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