3H-Thymidine labeling index, hormone receptors, and ploidy in breast cancers from elderly patients

B. Valentinis, R. Silvestrini, M. G. Daidone, D. Coradini, E. Galante, A. M. Cerrotta, G. Abolafio, L. Arboit

Research output: Contribution to journalArticle

Abstract

Breast cancers from 476 elderly patients, 70 years and older, operated on since 1972, were analyzed for proliferative activity, hormone receptors, and DNA content. Tumor proliferative activity, expressed as3H-thymidine labeling index (3H-TdR LI), had a median value of 3.4%, which progressively increased from 1972 to 1990. Estrogen and progesterone receptors were present respectively in 83% and 61% of the cases; the positivity for estrogen receptors slightly increased with time. Aneuploid clones were detected in 74% of the cases, and this incidence was relatively stable during the time of observation.3H-TdR LI, hormone receptors, and ploidy were generally unrelated to the local-regional extension of the disease in these elderly patients, in agreement with observations on cancer from younger patients. However, the absence of hormone receptors and the presence of aneuploidy were markedly indicative of fast cell proliferation. As in younger patients, these biologic findings in elderly patients could be considered as a complement to clinico-pathologic features in a 'risk-factor profile system' for treatment planning.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalBreast Cancer Research and Treatment
Volume20
Issue number1
DOIs
Publication statusPublished - Feb 1991

Keywords

  • breast cancer
  • cell proliferation
  • elderly patients
  • hormone receptors
  • ploidy
  • thymidine labeling index

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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