4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity

Luigi Scipione, Daniela De Vita, Alessandra Musella, Lisa Flammini, Simona Bertoni, Elisabetta Barocelli

Research output: Contribution to journalArticlepeer-review


Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats.

Original languageEnglish
Pages (from-to)309-312
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number1
Publication statusPublished - Jan 1 2008


  • 4-Aminopyridine derivatives
  • Acetylcholinesterase
  • Antiamnesic effects
  • Butyrylcholinesterase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science


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