41. Weaning from opioid therapy in children: A proposal for a protocol

C. Agosto, F. Benini, P. Logo, G. Carli, P. Cogo, F. Zacchello

Research output: Contribution to journalArticlepeer-review


Opioid drugs (particularly fentanyl and morphine) are very popular in the management of pediatric pain and sedation. Using opioids for prolonged therapies (> 5-7 days), tolerance and withdrawal symptoms could arise when abruptly stopped. Our study consists of a proposal for a protocol for weaning from opioid drugs. Goals: Controlling the abstinence symptoms. Carefully monitoring each weaning step, calculating every hour the Neonatal Abstinence Score and every two hours the Pediatric Abstinence Score obtaining a fast weaning in order to shorter the period of NICU and PICU hospitalization. Until now we have treated 10 children (0-15 yr.): all were sedated with continuous infusion of fentanyl (1-6 ug/kg/h) from 3 days to 6 weeks. We had severe abstinence signs only in two cases. The weaning periods were strongly correlated with the duration of opioid therapy. In two cases the final phases of weaning were done at home without problems.

Original languageEnglish
Pages (from-to)237
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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