TY - JOUR
T1 - 5-(2-bromoethyl)-2'deoxyuridine
T2 - A selective inhibitor of herpes simplex viruses in vitro
AU - La Colla, P.
AU - Pani, A.
AU - Marongiu, M. E.
AU - Corrias, M. V.
AU - Flore, O.
AU - Marcello, C.
AU - Lecca, U.
PY - 1989
Y1 - 1989
N2 - A new pyrimidine analog, 5-(2-bromoethyl)-2'-deoxyuridine (BEUdR), was tested in vitro for antiviral activity on Herpes simplex virus types 1 and 2. As reference compounds, ACG, BVUdR and PAA were used. Compared to ACG and BVUdR, BEUdR resulted less potent on both HSV-1 and HSV-2. However, a 50% inhibition of the multiplication of uninfected cells could be obtained only at very high BEUdR concentration (ID50 = 8500 μM). This makes BEUdR the least toxic analog known and gives it a selective index comparable to, if not better, than of ACG and BVUdR.
AB - A new pyrimidine analog, 5-(2-bromoethyl)-2'-deoxyuridine (BEUdR), was tested in vitro for antiviral activity on Herpes simplex virus types 1 and 2. As reference compounds, ACG, BVUdR and PAA were used. Compared to ACG and BVUdR, BEUdR resulted less potent on both HSV-1 and HSV-2. However, a 50% inhibition of the multiplication of uninfected cells could be obtained only at very high BEUdR concentration (ID50 = 8500 μM). This makes BEUdR the least toxic analog known and gives it a selective index comparable to, if not better, than of ACG and BVUdR.
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M3 - Article
C2 - 2713989
AN - SCOPUS:0024505972
VL - 16
SP - 16
EP - 20
JO - Clinical and Experimental Obstetrics and Gynecology
JF - Clinical and Experimental Obstetrics and Gynecology
SN - 0390-6663
IS - 1
ER -