5-(2-bromoethyl)-2'deoxyuridine: A selective inhibitor of herpes simplex viruses in vitro

P. La Colla, A. Pani, M. E. Marongiu, M. V. Corrias, O. Flore, C. Marcello, U. Lecca

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Abstract

A new pyrimidine analog, 5-(2-bromoethyl)-2'-deoxyuridine (BEUdR), was tested in vitro for antiviral activity on Herpes simplex virus types 1 and 2. As reference compounds, ACG, BVUdR and PAA were used. Compared to ACG and BVUdR, BEUdR resulted less potent on both HSV-1 and HSV-2. However, a 50% inhibition of the multiplication of uninfected cells could be obtained only at very high BEUdR concentration (ID50 = 8500 μM). This makes BEUdR the least toxic analog known and gives it a selective index comparable to, if not better, than of ACG and BVUdR.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalClinical and Experimental Obstetrics and Gynecology
Volume16
Issue number1
Publication statusPublished - 1989

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ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

La Colla, P., Pani, A., Marongiu, M. E., Corrias, M. V., Flore, O., Marcello, C., & Lecca, U. (1989). 5-(2-bromoethyl)-2'deoxyuridine: A selective inhibitor of herpes simplex viruses in vitro. Clinical and Experimental Obstetrics and Gynecology, 16(1), 16-20.