5-(2-bromoethyl)-2'deoxyuridine: A selective inhibitor of herpes simplex viruses in vitro

P. La Colla, A. Pani, M. E. Marongiu, M. V. Corrias, O. Flore, C. Marcello, U. Lecca

Research output: Contribution to journalArticlepeer-review


A new pyrimidine analog, 5-(2-bromoethyl)-2'-deoxyuridine (BEUdR), was tested in vitro for antiviral activity on Herpes simplex virus types 1 and 2. As reference compounds, ACG, BVUdR and PAA were used. Compared to ACG and BVUdR, BEUdR resulted less potent on both HSV-1 and HSV-2. However, a 50% inhibition of the multiplication of uninfected cells could be obtained only at very high BEUdR concentration (ID50 = 8500 μM). This makes BEUdR the least toxic analog known and gives it a selective index comparable to, if not better, than of ACG and BVUdR.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalClinical and Experimental Obstetrics and Gynecology
Issue number1
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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