Abstract
A new pyrimidine analog, 5-(2-bromoethyl)-2'-deoxyuridine (BEUdR), was tested in vitro for antiviral activity on Herpes simplex virus types 1 and 2. As reference compounds, ACG, BVUdR and PAA were used. Compared to ACG and BVUdR, BEUdR resulted less potent on both HSV-1 and HSV-2. However, a 50% inhibition of the multiplication of uninfected cells could be obtained only at very high BEUdR concentration (ID50 = 8500 μM). This makes BEUdR the least toxic analog known and gives it a selective index comparable to, if not better, than of ACG and BVUdR.
| Original language | English |
|---|---|
| Pages (from-to) | 16-20 |
| Number of pages | 5 |
| Journal | Clinical and Experimental Obstetrics and Gynecology |
| Volume | 16 |
| Issue number | 1 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
La Colla, P., Pani, A., Marongiu, M. E., Corrias, M. V., Flore, O., Marcello, C., & Lecca, U. (1989). 5-(2-bromoethyl)-2'deoxyuridine: A selective inhibitor of herpes simplex viruses in vitro. Clinical and Experimental Obstetrics and Gynecology, 16(1), 16-20.