5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias

A. Pinto, V. Attadia, A. Fusco, F. Ferrara, O. A. Spada, P. P. Di Fiore

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Abstract

In this study, the effects of 5-aza-2'-deoxycytidine on differentiation of human leukemic cells in primary suspension culture are reported for the first time. Morphological and functional differentiation was induced in cells from two acute monoblastic leukemias and two of three acute myeloid leukmias following repeated exposures to 1 μol/L 5-aza-2'-deoxycytidine. The observation that nontoxic concentrations of the drug are able to induce the in vitro differentiation of both monoblastic and myeloblastic leukemic cells into mature elements may encourage the exploitation of the differentiating properties of 5-aza-2'-deoxycytidine in chemotherapy protocols for acute non-lymphoblastic leukemias.

Original languageEnglish
Pages (from-to)922-928
Number of pages7
JournalBlood
Volume64
Issue number4
Publication statusPublished - 1984

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ASJC Scopus subject areas

  • Hematology

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