5 Glucocorticoids and the immune system in AIDS

Tarcisio Vago, Mario Clerici, Guido Norbiato

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Data reported in the literature show in the majority of cases an increased basal cortisol level in HIV-positive patients compared with controls, although the plasma concentration of cortisol in HIV-positive patients is generally within the physiological range. It is well known that pharmacological doses of glucocorticoids are immunosuppressive, but little is known about the effects of physiological concentrations of cortisol on the immune system. If a dialogue really exists between the HPA axis and the immune system, immune responses should be modulated by physiological concentrations of cortisol, as well as pathological levels of cortisol (high as in Cushing's syndrome or low as in Addison's disease), which are known to be associated with impaired immune system responses. We suggest that in HIV-positive patients, a chronic increase in the basal endogenous cortisol levels may provoke an imbalance in cytokine production, with a decrease in the production of type 1 and an increase in that of type 2. The type 1 to type 2 shift might be synergic with the increased cortisol levels in enhancing viral replication and apoptotic phenomena, and finally in causing the progression of HIV infection.

Original languageEnglish
Pages (from-to)789-802
Number of pages14
JournalBailliere's Clinical Endocrinology and Metabolism
Volume8
Issue number4
DOIs
Publication statusPublished - 1994

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Immune system
Glucocorticoids
Hydrocortisone
Immune System
Acquired Immunodeficiency Syndrome
HIV
Addison Disease
Cushing Syndrome
Immunosuppressive Agents
HIV Infections
Pharmacology
Cytokines
Plasmas

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

5 Glucocorticoids and the immune system in AIDS. / Vago, Tarcisio; Clerici, Mario; Norbiato, Guido.

In: Bailliere's Clinical Endocrinology and Metabolism, Vol. 8, No. 4, 1994, p. 789-802.

Research output: Contribution to journalArticle

Vago, Tarcisio ; Clerici, Mario ; Norbiato, Guido. / 5 Glucocorticoids and the immune system in AIDS. In: Bailliere's Clinical Endocrinology and Metabolism. 1994 ; Vol. 8, No. 4. pp. 789-802.
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