5-grass pollen tablets achieve disease control in patients with seasonal allergic rhinitis unresponsive to drugs: A real-life study

Elide Anna Pastorello, Laura Losappio, Stefania Milani, Giuseppina Manzotti, Valentina Fanelli, Valerio Pravettoni, Fabio Agostinis, Alberto Flores D'Arcais, Ilaria Dell'Albani, Paola Puccinelli, Cristoforo Incorvaia, Franco Frati

Research output: Contribution to journalArticle

Abstract

Background: An important subpopulation in allergic rhinitis is represented by patients with severe form of disease that is not responsive to drug treatment. It has been reported that grass pollen subcutaneous immunotherapy is effective in drug-resistant patients. In a real-life study, we evaluated the efficacy of 5-grass pollen tablets in patients with grass pollen-induced allergic rhinitis not responsive to drug therapy. Methods: We carried out this multicenter observational study in adults and adolescents with grass-induced allergic rhinitis not responsive to drug therapy who were treated for a year with 5-grass pollen tablets. Clinical data collected before and after sublingual immunotherapy (SLIT) included Allergic Rhinitis and its Impact on Asthma (ARIA) classification of allergic rhinitis, response to therapy, and patient satisfaction. Results: Forty-seven patients entered the study. By ARIA classification, three patients had moderate to severe intermittent allergic rhinitis, ten had mild persistent allergic rhinitis, and 34 had moderate to severe persistent allergic rhinitis. There were no cases of mild intermittent allergic rhinitis before SLIT. After SLIT, 33 patients had mild intermittent allergic rhinitis, none had moderate to severe intermittent allergic rhinitis, seven had mild persistent allergic rhinitis, and seven had moderate to severe persistent allergic rhinitis. The mean medication score decreased from 4.2±1.3 before to 2.4±2.0 after SLIT (P

Original languageEnglish
Pages (from-to)127-133
Number of pages7
JournalJournal of Asthma and Allergy
Issue number6
DOIs
Publication statusPublished - 2013

Keywords

  • Allergen immunotherapy
  • Drug resistance
  • Effectiveness
  • Grass pollen
  • Patient satisfaction
  • Rhinitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of '5-grass pollen tablets achieve disease control in patients with seasonal allergic rhinitis unresponsive to drugs: A real-life study'. Together they form a unique fingerprint.

  • Cite this

    Pastorello, E. A., Losappio, L., Milani, S., Manzotti, G., Fanelli, V., Pravettoni, V., Agostinis, F., D'Arcais, A. F., Dell'Albani, I., Puccinelli, P., Incorvaia, C., & Frati, F. (2013). 5-grass pollen tablets achieve disease control in patients with seasonal allergic rhinitis unresponsive to drugs: A real-life study. Journal of Asthma and Allergy, (6), 127-133. https://doi.org/10.2147/JAA.S53801