5-HT1A polymorphism and self-transcendence in mood disorders

Cristina Lorenzi, Alessandro Serretti, Laura Mandelli, Viviana Tubazio, Cristina Ploia, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review


Recently, an association between serotonin 1A receptor binding potential and self-transcendence scores at the temperament and character inventory (TCI) has been reported. We tested involvement of 5-HT1A gene in this trait, in a sample of 40 remitted mood disorder patients. Subjects with the 5-HT1A*C/C genotype showed significantly lower scores at the total self-transcendence and at the sub-scales of transpersonal identification and spiritual acceptance. Our preliminary results further support the involvement of the serotoninergic pattern in the self-transcendence character trait.

Original languageEnglish
Pages (from-to)33-35
Number of pages3
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume137 B
Issue number1
Publication statusPublished - Aug 5 2005


  • Behavior
  • Character
  • Serotonin
  • Spirituality

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)


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