Abstract
Involvement of the cerebral serotoninergic system has been invoked to explain the origin of the pain and the vascular phenomena in migraine. To further investigate the type of cerebral serotonin receptors that may be altered in migraine, the prolactin (PRL) and cortisol responses to m- chlorophenylpiperazine (mCPP), a selective 5-HT(1A),-5-HT(2A/C) receptor agonist, were monitored in 12 patients suffering from migraine without aura and in 14 matched healthy controls. Each subject underwent two challenges, one with mCPP (0.5 mg/kg) and the other with placebo (orally) using a double- blind crossover design. Anxiety level was measured by the State Trait Anxiety Inventory. Migraine patients had a greater PRL response to mCPP (p = 0.05) and greater anxiety (p
Original language | English |
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Pages (from-to) | 2605-2608 |
Number of pages | 4 |
Journal | NeuroReport |
Volume | 9 |
Issue number | 11 |
Publication status | Published - Aug 3 1998 |
Keywords
- Anxiety
- m- Chlorophenylpiperazine
- Migraine
- Pathogenesis
- Prolactin
- Serotonin
- Stress
ASJC Scopus subject areas
- Neuroscience(all)