5-HT(1A) receptor hypersensitivity in migraine is suggested by the m- chlorophenylpiperazine test

Massimo Leone; Angelo Attanasio; Danilo Croci; Alessandra Ferraris; Domenico D'Amico; Licia Grazzi; Angelo Nespolo; Gennaro Bussone

5-HT(1A) receptor hypersensitivity in migraine is suggested by the m- chlorophenylpiperazine test

Massimo Leone, Angelo Attanasio, Danilo Croci, Alessandra Ferraris, Domenico D'Amico, Licia Grazzi, Angelo Nespolo, Gennaro Bussone

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

Involvement of the cerebral serotoninergic system has been invoked to explain the origin of the pain and the vascular phenomena in migraine. To further investigate the type of cerebral serotonin receptors that may be altered in migraine, the prolactin (PRL) and cortisol responses to m- chlorophenylpiperazine (mCPP), a selective 5-HT(1A),-5-HT(2A/C) receptor agonist, were monitored in 12 patients suffering from migraine without aura and in 14 matched healthy controls. Each subject underwent two challenges, one with mCPP (0.5 mg/kg) and the other with placebo (orally) using a double- blind crossover design. Anxiety level was measured by the State Trait Anxiety Inventory. Migraine patients had a greater PRL response to mCPP (p = 0.05) and greater anxiety (p

Original language	English
Pages (from-to)	2605-2608
Number of pages	4
Journal	NeuroReport
Volume	9
Issue number	11
Publication status	Published - Aug 3 1998

Keywords

Anxiety
m- Chlorophenylpiperazine
Migraine
Pathogenesis
Prolactin
Serotonin
Stress

ASJC Scopus subject areas

Neuroscience(all)

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abstract = "Involvement of the cerebral serotoninergic system has been invoked to explain the origin of the pain and the vascular phenomena in migraine. To further investigate the type of cerebral serotonin receptors that may be altered in migraine, the prolactin (PRL) and cortisol responses to m- chlorophenylpiperazine (mCPP), a selective 5-HT(1A),-5-HT(2A/C) receptor agonist, were monitored in 12 patients suffering from migraine without aura and in 14 matched healthy controls. Each subject underwent two challenges, one with mCPP (0.5 mg/kg) and the other with placebo (orally) using a double- blind crossover design. Anxiety level was measured by the State Trait Anxiety Inventory. Migraine patients had a greater PRL response to mCPP (p = 0.05) and greater anxiety (p",

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author = "Massimo Leone and Angelo Attanasio and Danilo Croci and Alessandra Ferraris and Domenico D'Amico and Licia Grazzi and Angelo Nespolo and Gennaro Bussone",

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AU - Croci, Danilo

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AU - D'Amico, Domenico

AU - Grazzi, Licia

AU - Nespolo, Angelo

AU - Bussone, Gennaro

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