Abstract
Involvement of the cerebral serotoninergic system has been invoked to explain the origin of the pain and the vascular phenomena in migraine. To further investigate the type of cerebral serotonin receptors that may be altered in migraine, the prolactin (PRL) and cortisol responses to m- chlorophenylpiperazine (mCPP), a selective 5-HT(1A),-5-HT(2A/C) receptor agonist, were monitored in 12 patients suffering from migraine without aura and in 14 matched healthy controls. Each subject underwent two challenges, one with mCPP (0.5 mg/kg) and the other with placebo (orally) using a double- blind crossover design. Anxiety level was measured by the State Trait Anxiety Inventory. Migraine patients had a greater PRL response to mCPP (p = 0.05) and greater anxiety (p
| Original language | English |
|---|---|
| Pages (from-to) | 2605-2608 |
| Number of pages | 4 |
| Journal | NeuroReport |
| Volume | 9 |
| Issue number | 11 |
| Publication status | Published - Aug 3 1998 |
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Keywords
- Anxiety
- m- Chlorophenylpiperazine
- Migraine
- Pathogenesis
- Prolactin
- Serotonin
- Stress
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
5-HT(1A) receptor hypersensitivity in migraine is suggested by the m- chlorophenylpiperazine test. / Leone, Massimo; Attanasio, Angelo; Croci, Danilo; Ferraris, Alessandra; D'Amico, Domenico; Grazzi, Licia; Nespolo, Angelo; Bussone, Gennaro.
In: NeuroReport, Vol. 9, No. 11, 03.08.1998, p. 2605-2608.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 5-HT(1A) receptor hypersensitivity in migraine is suggested by the m- chlorophenylpiperazine test
AU - Leone, Massimo
AU - Attanasio, Angelo
AU - Croci, Danilo
AU - Ferraris, Alessandra
AU - D'Amico, Domenico
AU - Grazzi, Licia
AU - Nespolo, Angelo
AU - Bussone, Gennaro
PY - 1998/8/3
Y1 - 1998/8/3
N2 - Involvement of the cerebral serotoninergic system has been invoked to explain the origin of the pain and the vascular phenomena in migraine. To further investigate the type of cerebral serotonin receptors that may be altered in migraine, the prolactin (PRL) and cortisol responses to m- chlorophenylpiperazine (mCPP), a selective 5-HT(1A),-5-HT(2A/C) receptor agonist, were monitored in 12 patients suffering from migraine without aura and in 14 matched healthy controls. Each subject underwent two challenges, one with mCPP (0.5 mg/kg) and the other with placebo (orally) using a double- blind crossover design. Anxiety level was measured by the State Trait Anxiety Inventory. Migraine patients had a greater PRL response to mCPP (p = 0.05) and greater anxiety (p
AB - Involvement of the cerebral serotoninergic system has been invoked to explain the origin of the pain and the vascular phenomena in migraine. To further investigate the type of cerebral serotonin receptors that may be altered in migraine, the prolactin (PRL) and cortisol responses to m- chlorophenylpiperazine (mCPP), a selective 5-HT(1A),-5-HT(2A/C) receptor agonist, were monitored in 12 patients suffering from migraine without aura and in 14 matched healthy controls. Each subject underwent two challenges, one with mCPP (0.5 mg/kg) and the other with placebo (orally) using a double- blind crossover design. Anxiety level was measured by the State Trait Anxiety Inventory. Migraine patients had a greater PRL response to mCPP (p = 0.05) and greater anxiety (p
KW - Anxiety
KW - m- Chlorophenylpiperazine
KW - Migraine
KW - Pathogenesis
KW - Prolactin
KW - Serotonin
KW - Stress
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UR - http://www.scopus.com/inward/citedby.url?scp=0032479593&partnerID=8YFLogxK
M3 - Article
C2 - 9721941
AN - SCOPUS:0032479593
VL - 9
SP - 2605
EP - 2608
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 11
ER -