5-HT(1A) receptor hypersensitivity in migraine is suggested by the m- chlorophenylpiperazine test

Massimo Leone, Angelo Attanasio, Danilo Croci, Alessandra Ferraris, Domenico D'Amico, Licia Grazzi, Angelo Nespolo, Gennaro Bussone

Research output: Contribution to journalArticle

Abstract

Involvement of the cerebral serotoninergic system has been invoked to explain the origin of the pain and the vascular phenomena in migraine. To further investigate the type of cerebral serotonin receptors that may be altered in migraine, the prolactin (PRL) and cortisol responses to m- chlorophenylpiperazine (mCPP), a selective 5-HT(1A),-5-HT(2A/C) receptor agonist, were monitored in 12 patients suffering from migraine without aura and in 14 matched healthy controls. Each subject underwent two challenges, one with mCPP (0.5 mg/kg) and the other with placebo (orally) using a double- blind crossover design. Anxiety level was measured by the State Trait Anxiety Inventory. Migraine patients had a greater PRL response to mCPP (p = 0.05) and greater anxiety (p

Original languageEnglish
Pages (from-to)2605-2608
Number of pages4
JournalNeuroReport
Volume9
Issue number11
Publication statusPublished - Aug 3 1998

Fingerprint

Receptor, Serotonin, 5-HT1A
Migraine Disorders
Hypersensitivity
Anxiety
Prolactin
Migraine without Aura
Receptor, Serotonin, 5-HT2A
Serotonin Receptors
Cross-Over Studies
Blood Vessels
Hydrocortisone
Serotonin
Placebos
Pain
Equipment and Supplies
1-(3-chlorophenyl)piperazine

Keywords

  • Anxiety
  • m- Chlorophenylpiperazine
  • Migraine
  • Pathogenesis
  • Prolactin
  • Serotonin
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

5-HT(1A) receptor hypersensitivity in migraine is suggested by the m- chlorophenylpiperazine test. / Leone, Massimo; Attanasio, Angelo; Croci, Danilo; Ferraris, Alessandra; D'Amico, Domenico; Grazzi, Licia; Nespolo, Angelo; Bussone, Gennaro.

In: NeuroReport, Vol. 9, No. 11, 03.08.1998, p. 2605-2608.

Research output: Contribution to journalArticle

Leone, M, Attanasio, A, Croci, D, Ferraris, A, D'Amico, D, Grazzi, L, Nespolo, A & Bussone, G 1998, '5-HT(1A) receptor hypersensitivity in migraine is suggested by the m- chlorophenylpiperazine test', NeuroReport, vol. 9, no. 11, pp. 2605-2608.
Leone, Massimo ; Attanasio, Angelo ; Croci, Danilo ; Ferraris, Alessandra ; D'Amico, Domenico ; Grazzi, Licia ; Nespolo, Angelo ; Bussone, Gennaro. / 5-HT(1A) receptor hypersensitivity in migraine is suggested by the m- chlorophenylpiperazine test. In: NeuroReport. 1998 ; Vol. 9, No. 11. pp. 2605-2608.
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