5-HT(1A) receptor hypersensitivity in migraine is suggested by the m- chlorophenylpiperazine test

Massimo Leone, Angelo Attanasio, Danilo Croci, Alessandra Ferraris, Domenico D'Amico, Licia Grazzi, Angelo Nespolo, Gennaro Bussone

Research output: Contribution to journalArticlepeer-review

Abstract

Involvement of the cerebral serotoninergic system has been invoked to explain the origin of the pain and the vascular phenomena in migraine. To further investigate the type of cerebral serotonin receptors that may be altered in migraine, the prolactin (PRL) and cortisol responses to m- chlorophenylpiperazine (mCPP), a selective 5-HT(1A),-5-HT(2A/C) receptor agonist, were monitored in 12 patients suffering from migraine without aura and in 14 matched healthy controls. Each subject underwent two challenges, one with mCPP (0.5 mg/kg) and the other with placebo (orally) using a double- blind crossover design. Anxiety level was measured by the State Trait Anxiety Inventory. Migraine patients had a greater PRL response to mCPP (p = 0.05) and greater anxiety (p

Original languageEnglish
Pages (from-to)2605-2608
Number of pages4
JournalNeuroReport
Volume9
Issue number11
Publication statusPublished - Aug 3 1998

Keywords

  • Anxiety
  • m- Chlorophenylpiperazine
  • Migraine
  • Pathogenesis
  • Prolactin
  • Serotonin
  • Stress

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of '5-HT(1A) receptor hypersensitivity in migraine is suggested by the m- chlorophenylpiperazine test'. Together they form a unique fingerprint.

Cite this