5-HT2A SNPs and the Temperament and Character Inventory

Alessandro Serretti, Raffaella Calati, Ina Giegling, Annette M. Hartmann, Hans Jürgen Möller, Cristina Colombo, Dan Rujescu

Research output: Contribution to journalArticle


Temperamental traits, the most basic part of personality, have been largely correlated with neurotransmitter systems and are under genetic control. Among serotonin candidates, the 2A receptor (5-HT2A) received considerable attention. We analyzed four SNPs (rs643627, rs594242, rs6311 and rs6313) in the 5-HT2A gene and their association with personality traits, as measured with the Temperament and Character Inventory (TCI). The sample was composed of three sub-groups: two German sub-samples, consisting of a healthy group of 289 subjects (42.6% males, mean age: 45.2 ± 14.9) and a psychiatric patient group of 111 suicide attempters (38.7% males, mean age: 39.2 ± 13.6), and an Italian sub-sample, composed of 60 mood disorder patients (35.0% males, mean age: 44.0 ± 14.8). Controlling for sex, age and educational level, the SNPs were not strongly associated with personality dimensions. Only the rs594242 showed an association with Self-Directedness (p = 0.003) in the German sample, while rs6313 was marginally associated with Novelty Seeking (p = 0.01) in the Italian sample. We conclude that 5-HT2A SNPs may marginally modulate personality traits but further studies are required.

Original languageEnglish
Pages (from-to)1275-1281
Number of pages7
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number6
Publication statusPublished - Aug 15 2007



  • 5-HT
  • Character
  • Personality
  • TCI
  • Temperament

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Serretti, A., Calati, R., Giegling, I., Hartmann, A. M., Möller, H. J., Colombo, C., & Rujescu, D. (2007). 5-HT2A SNPs and the Temperament and Character Inventory. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31(6), 1275-1281. https://doi.org/10.1016/j.pnpbp.2007.05.008