Temperamental traits, the most basic part of personality, have been largely correlated with neurotransmitter systems and are under genetic control. Among serotonin candidates, the 2A receptor (5-HT2A) received considerable attention. We analyzed four SNPs (rs643627, rs594242, rs6311 and rs6313) in the 5-HT2A gene and their association with personality traits, as measured with the Temperament and Character Inventory (TCI). The sample was composed of three sub-groups: two German sub-samples, consisting of a healthy group of 289 subjects (42.6% males, mean age: 45.2 ± 14.9) and a psychiatric patient group of 111 suicide attempters (38.7% males, mean age: 39.2 ± 13.6), and an Italian sub-sample, composed of 60 mood disorder patients (35.0% males, mean age: 44.0 ± 14.8). Controlling for sex, age and educational level, the SNPs were not strongly associated with personality dimensions. Only the rs594242 showed an association with Self-Directedness (p = 0.003) in the German sample, while rs6313 was marginally associated with Novelty Seeking (p = 0.01) in the Italian sample. We conclude that 5-HT2A SNPs may marginally modulate personality traits but further studies are required.
|Number of pages||7|
|Journal||Progress in Neuro-Psychopharmacology and Biological Psychiatry|
|Publication status||Published - Aug 15 2007|
ASJC Scopus subject areas
- Biological Psychiatry