5-HT3 receptor antagonists do not modify cocaine place conditioning or the rise in extracellular dopamine in the nucleus accumbens of rats

Luigi Cervo, Laura Pozzi, Rosario Samanin

Research output: Contribution to journalArticle

Abstract

Three 5HT3 receptor antagonists, MDL 72222, tropisetron, and ondansetron were studied for their ability to modify the conditioned place preference (CPP) induced by 10 mg/kg IP cocaine in rats. MDL 72222 (0.03-3 mg/kg SC) and tropisetron (0.01-0.1 mg/kg SC) administered, respectively, 30 min and 1 h before each conditioning session, did not affect the acquisition of cocaine CPP. Ondansetron (0.01-0.1 mg/kg SC) administered 30 min before each conditioning session or just before testing likewise had no effect. At 0.1 mg/kg SC ondansetron did not modify the increase of extracellular dopamine caused by 10 mg/kg cocaine in the nucleus accumbens. The results suggest that 5-HT3 receptor antagonists have no effect on the rewarding properties of cocaine or on the behaviour elicited by the stimuli previously associated with the drug's action.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume55
Issue number1
DOIs
Publication statusPublished - Sep 1996

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Keywords

  • 5-HT receptor antagonists
  • Cocaine
  • Conditioned place preference
  • MDL 72222
  • Tropisetron

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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