5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO

G. Piechele, S. Colli, E. Tremoli, A. Maggi

Research output: Contribution to journalArticle

Abstract

The model of promyelocytic leukemia cells HL60 was utilized to study the accumulation of 5-lipoxygenase mRNA during the cellular differentiation induced by DMSO. In the present study a strict correlation between the increase in state of differentiation of HL60 and accumulation of 5-lipoxygenase mRNA is demonstrated, indicating that HL60 cells are an interesting model for the study of drugs which could interfere with the synthesis of the enzyme.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalPharmacological Research
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 1993

Fingerprint

Arachidonate 5-Lipoxygenase
HL-60 Cells
Dimethyl Sulfoxide
Cell Differentiation
Gene Expression
Messenger RNA
Leukemia
Enzymes
Pharmaceutical Preparations

Keywords

  • HL60 cells, human 5-lipoxygenase

ASJC Scopus subject areas

  • Pharmacology

Cite this

5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO. / Piechele, G.; Colli, S.; Tremoli, E.; Maggi, A.

In: Pharmacological Research, Vol. 27, No. 1, 01.1993, p. 53-60.

Research output: Contribution to journalArticle

Piechele, G. ; Colli, S. ; Tremoli, E. ; Maggi, A. / 5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO. In: Pharmacological Research. 1993 ; Vol. 27, No. 1. pp. 53-60.
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