5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO

G. Piechele, S. Colli, E. Tremoli, A. Maggi

Research output: Contribution to journalArticlepeer-review


The model of promyelocytic leukemia cells HL60 was utilized to study the accumulation of 5-lipoxygenase mRNA during the cellular differentiation induced by DMSO. In the present study a strict correlation between the increase in state of differentiation of HL60 and accumulation of 5-lipoxygenase mRNA is demonstrated, indicating that HL60 cells are an interesting model for the study of drugs which could interfere with the synthesis of the enzyme.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalPharmacological Research
Issue number1
Publication statusPublished - Jan 1993


  • HL60 cells, human 5-lipoxygenase

ASJC Scopus subject areas

  • Pharmacology


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