Abstract
The model of promyelocytic leukemia cells HL60 was utilized to study the accumulation of 5-lipoxygenase mRNA during the cellular differentiation induced by DMSO. In the present study a strict correlation between the increase in state of differentiation of HL60 and accumulation of 5-lipoxygenase mRNA is demonstrated, indicating that HL60 cells are an interesting model for the study of drugs which could interfere with the synthesis of the enzyme.
| Original language | English |
|---|---|
| Pages (from-to) | 53-60 |
| Number of pages | 8 |
| Journal | Pharmacological Research |
| Volume | 27 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1993 |
Fingerprint
Keywords
- HL60 cells, human 5-lipoxygenase
ASJC Scopus subject areas
- Pharmacology
Cite this
5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO. / Piechele, G.; Colli, S.; Tremoli, E.; Maggi, A.
In: Pharmacological Research, Vol. 27, No. 1, 01.1993, p. 53-60.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 5-Lipoxygenase gene expression in HL60 cells during differentiation with DMSO
AU - Piechele, G.
AU - Colli, S.
AU - Tremoli, E.
AU - Maggi, A.
PY - 1993/1
Y1 - 1993/1
N2 - The model of promyelocytic leukemia cells HL60 was utilized to study the accumulation of 5-lipoxygenase mRNA during the cellular differentiation induced by DMSO. In the present study a strict correlation between the increase in state of differentiation of HL60 and accumulation of 5-lipoxygenase mRNA is demonstrated, indicating that HL60 cells are an interesting model for the study of drugs which could interfere with the synthesis of the enzyme.
AB - The model of promyelocytic leukemia cells HL60 was utilized to study the accumulation of 5-lipoxygenase mRNA during the cellular differentiation induced by DMSO. In the present study a strict correlation between the increase in state of differentiation of HL60 and accumulation of 5-lipoxygenase mRNA is demonstrated, indicating that HL60 cells are an interesting model for the study of drugs which could interfere with the synthesis of the enzyme.
KW - HL60 cells, human 5-lipoxygenase
UR - http://www.scopus.com/inward/record.url?scp=0027417115&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027417115&partnerID=8YFLogxK
U2 - 10.1006/phrs.1993.1005
DO - 10.1006/phrs.1993.1005
M3 - Article
C2 - 8456058
AN - SCOPUS:0027417115
VL - 27
SP - 53
EP - 60
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
IS - 1
ER -