The rate of low-grade gliomas that recur at higher histological grade is estimated from 13 to 85%. This wide range indicates the difficulty to ascertain this event, which is in most cases only presumed without histological confirmation. A series of 131 low-grade gliomas of the cerebral hemispheres surgically treated in the period 1978-1989 has been analyzed. Forty-two were fibrillary astrocytomas (A), 49 mixed oligo-astrocytomas (OA), 29 oligodendrogliomas (O) and 11 gemistocytic astrocytomas (AG). The period of clinical observation ranged from 48 to 192 months, the mean follow-up being 97.02 (+/-52.81 months). The m.s.t. of the whole group was 144 months. Thirty-nine tumours (29.9%) were reoperated for recurrence: eight recurred after previous complete removal (6 were AG) and 31 after subtotal or partial resection. In 10 was confirmed the previous diagnosis, while 29 (22.13%) progressed towards higher histological grade. The rate of tumour progression for histotype was 24.13% for OA (5 AA and 2 GBM), 23.8% for A (8 AA and 2 GBM), 83.3% for AG (3 AA and 6 GBM) and 6.12 % for O (all anaplastic oligodendrogliomas). The proportion of progression in the tumours reoperated for recurrence was 74.35%. - These data indicate that, although difficult to estimate, progression remains a frequent event in cerebral gliomas. - Its highest occurrence is observed in gemistocytic astrocytomas, while it seems less likely in oligodendrogliomas. - The rate of recurrence and progression seems to correlate with the extent of surgical resection. - In case of recurrence histological confirmation should be considered, especially when complementary therapies (radio- or chemotherapy) can be offered.
|Number of pages||1|
|Journal||Italian Journal of Neurological Sciences|
|Publication status||Published - 1997|
ASJC Scopus subject areas
- Clinical Neurology