54. Obesity and thrombophilia: Is fibrinogen the missed link?

F. Marietta, S. Dorini, B. Paleari, P. Fanari, R. Agosti, P. Cherubini, M. L. Petroni, L. Manghisi, F. Balzola, E. Longhini

Research output: Contribution to journalArticle

Abstract

The aim of our study was to search for correlations between obesity and the high incidence of cardiovascular events. It is known that obese patients show alterations of many metabolic, hématologie, hemorheologic and coagulative parameters. It is also known that fibrinogen is a cardiovascular risk factor and that it is always increased in obese patients. We studied 12 adult (7 F and 5 M, aged 48-56) with BMI higher than 48 (50.3±3.8, mean±S.D.). All patients underwent a period of hypocaloric diet following a standard diet protocol. None of them was diabetic, hypertensive or with other diseases related to cardiovascular risk. We determined hemorheologic parameters (Ht, plasma and blood viscosity, erythrocyte aggregation and whole blood filtration), fibrinogen, cholesterol, triglicerides, PT and aPTT. We found a significant increase in both basal blood viscosity and fibrinogen which decreased after the diet period associated to an improvement of all the Theological data. Our results suggest that the relation between obesity and cardiovascular risk may not be simply due to the high weight itself but to the interactions among many different factors all leading to an alteration of fibrinogen synthesis. This latter may play its role causing a microcirculatory organ damage by means of a rhéologie derangement of blood flow behaviour.

Original languageEnglish
Pages (from-to)17
Number of pages1
JournalFibrinolysis
Volume10
Issue numberSUPPL. 1
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Hematology

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