5q- In a case of chronic myelogenous leukemia relapsed after allogeneic bone marrow transplantation

D. Soligo, L. Romitti, V. Bertolli, A. Della Volpe, C. Annaloro, G. Lambertenghi Deliliers

Research output: Contribution to journalArticlepeer-review

Abstract

Clonal chromosome and/or hematological abnormalities typically observed in myelodysplastic syndromes (MDS) have been described with increased frequency after autologous bone marrow transplantation (BMT) for lymphoma. We report the case of a woman with chronic myelogenous leukemia (CML) allografted with her HLA-identical sibling who, 5 years after the transplant and under immunosuppressive treatment for chronic graft host disease (GVHD), suffered a cytogenetic relapse associated with a 5q- deletion in the host metaphases. These findings suggest that myelodysplastic changes, possibly related to the chemo-radiotherapy conditioning regimen, may also present after allogeneic BMT.

Original languageEnglish
Pages (from-to)437-439
Number of pages3
JournalHaematologica
Volume80
Issue number5
Publication statusPublished - 1995

Keywords

  • Bone marrow transplantation
  • Chronic myelogenous leukemia
  • Cytogenetics
  • Myelodysplastic syndromes

ASJC Scopus subject areas

  • Hematology

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