68Ga-citrate PET/CT for evaluating patients with infections of the bone: Preliminary results

Cristina Nanni, Costantino Errani, Luca Boriani, Lorenzo Fantini, Valentina Ambrosini, Stefano Boschi, Domenico Rubello, Cinzia Pettinato, Mario Mercuri, Alessandro Gasbarrini, Stefano Fanti

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this work was to preliminarily evaluate the sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy of 68Ga-citrate PET/CT in a population of patients with suspected bone infections. Methods: We enrolled 31 patients with suspected osteomyelitis or diskitis who underwent a total of forty 68Ga-citrate PET/CT scans. The results were compared with different combinations of diagnostic procedures (MRI, radiography, CT, or white blood cell scintigraphy), biopsy (when diagnostic), and follow-up data (at least 1 y) to determine the performance of 68Ga-citrate PET/CT. Results: We found a sensitivity of 100%, a specificity of 76%, a positive predictive value of 85%, a negative predictive value of 100%, and an overall accuracy of 90%. Conclusion: Although preliminary, these data confirm a possible role for 68Ga-citrate in the diagnosis of bone infections, especially in consideration of its favorable characteristics.

Original languageEnglish
Pages (from-to)1932-1936
Number of pages5
JournalJournal of Nuclear Medicine
Volume51
Issue number12
DOIs
Publication statusPublished - Dec 1 2010

Keywords

  • Ga-citrate
  • Bone infections
  • PET/CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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