7-Hexanoyltaxol-eluting stent for prevention of neointimal growth: An intravascular ultrasound analysis from the study to compare restenosis rate between QueST and QuaDS-QP2 (SCORE)

Toru Kataoka, Eberhard Grube, Yasuhiro Honda, Yoshihiro Morino, Seung H. Hur, Heidi N. Bonneau, Antonio Colombo, Carlo Di Mario, Giulio Guagliumi, Karl E. Hauptmann, Mark R. Pitney, Alexandra J. Lansky, Simon H. Stertzer, Paul G. Yock, Peter J. Fitzgerald

Research output: Contribution to journalArticle

Abstract

Background - Inhibition of neointimal tissue growth has been demonstrated in preliminary human feasibility studies with a stent-based polymer sleeve delivering 7-hexanoyltaxol. The Study to COmpare REstenosis rate between QueST and QuaDS-QP2 (SCORE) trial is a human, randomized, multicenter trial comparing 7-hexanoyltaxol (QP2)-eluting stents (qDES) with bare metal stents (BMS) in the treatment of de novo coronary lesions. The purpose of this substudy was to evaluate the acute expansion property and long-term neointimal responses of qDES compared with BMS as assessed by intravascular ultrasound (IVUS). Methods and Results - A total of 122 (qDES 66, BMS 56) patients were enrolled into the IVUS substudy. All IVUS images (immediately after the procedure and at 6-month follow-up) were analyzed at an independent core laboratory in a blind manner. At baseline, qDES achieved stent expansion similar to BMS. At follow-up, qDES showed reduced neointimal growth by 70% at the tightest cross section and by 68% over the stented segment (P

Original languageEnglish
Pages (from-to)1788-1793
Number of pages6
JournalCirculation
Volume106
Issue number14
DOIs
Publication statusPublished - Oct 1 2002

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Keywords

  • Cardiovascular diseases
  • Drugs
  • Restenosis
  • Stents
  • Ultrasonics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Kataoka, T., Grube, E., Honda, Y., Morino, Y., Hur, S. H., Bonneau, H. N., Colombo, A., Di Mario, C., Guagliumi, G., Hauptmann, K. E., Pitney, M. R., Lansky, A. J., Stertzer, S. H., Yock, P. G., & Fitzgerald, P. J. (2002). 7-Hexanoyltaxol-eluting stent for prevention of neointimal growth: An intravascular ultrasound analysis from the study to compare restenosis rate between QueST and QuaDS-QP2 (SCORE). Circulation, 106(14), 1788-1793. https://doi.org/10.1161/01.CIR.0000031734.11420.1C