7T μMRI of mesenteric venous ischemia in a rat model: Timing of the appearance of findings

Francesco Somma, Daniela Berritto, Francesca Iacobellis, Nicola Landi, Carlo Cavaliere, Marco Corona, Serena Russo, Roberto Di Mizio, Antonio Rotondo, Roberto Grassi

Research output: Contribution to journalArticlepeer-review


Objectives: The aim of this study is to analyze the chronological development of macroscopic, microscopic and magnetic resonance imaging (MRI) findings in a rat model of Superior Mesenteric Venous (SMV) ligation, and to evaluate the role of MRI in the diagnosis of mesenteric venous thrombosis. Methods: Thirty adult Sprague-Dawley rats were used and divided in two different groups that underwent a different surgical model and a different monitoring of ischemic damage. Group I underwent macroscopical and histological observation; Group II underwent 7. T μMRI evaluation and histological analysis. Results: The first alterations occurred 30. min after SMV ligation and progressively worsened until the eighth hour. The morphological and MRI findings showed the same course. Conclusions: This study provides a systematic evaluation of early anatomopathological and MRI findings following the SMV ligation. MRI allows to identify the early pathological findings of venous mesenteric ischemia and allows to correlate those to the histopathological features. Our data suggest a relevant role of MRI in the diagnostic management of mesenteric venous thrombosis, allowing to non-invasively identify and characterize the histopathologic findings. So, thanks to these skills, its future application in early diagnosis of human mesenteric venous ischemia is supposable.

Original languageEnglish
Pages (from-to)408-413
Number of pages6
JournalMagnetic Resonance Imaging
Issue number3
Publication statusPublished - Apr 2013


  • Animal models
  • Magnetic Resonance Imaging
  • Mesenteric veins venous thrombosis
  • Rats Sprague-Dawley

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering


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