TY - JOUR
T1 - 7T μMRI of mesenteric venous ischemia in a rat model
T2 - Timing of the appearance of findings
AU - Somma, Francesco
AU - Berritto, Daniela
AU - Iacobellis, Francesca
AU - Landi, Nicola
AU - Cavaliere, Carlo
AU - Corona, Marco
AU - Russo, Serena
AU - Di Mizio, Roberto
AU - Rotondo, Antonio
AU - Grassi, Roberto
PY - 2013/4
Y1 - 2013/4
N2 - Objectives: The aim of this study is to analyze the chronological development of macroscopic, microscopic and magnetic resonance imaging (MRI) findings in a rat model of Superior Mesenteric Venous (SMV) ligation, and to evaluate the role of MRI in the diagnosis of mesenteric venous thrombosis. Methods: Thirty adult Sprague-Dawley rats were used and divided in two different groups that underwent a different surgical model and a different monitoring of ischemic damage. Group I underwent macroscopical and histological observation; Group II underwent 7. T μMRI evaluation and histological analysis. Results: The first alterations occurred 30. min after SMV ligation and progressively worsened until the eighth hour. The morphological and MRI findings showed the same course. Conclusions: This study provides a systematic evaluation of early anatomopathological and MRI findings following the SMV ligation. MRI allows to identify the early pathological findings of venous mesenteric ischemia and allows to correlate those to the histopathological features. Our data suggest a relevant role of MRI in the diagnostic management of mesenteric venous thrombosis, allowing to non-invasively identify and characterize the histopathologic findings. So, thanks to these skills, its future application in early diagnosis of human mesenteric venous ischemia is supposable.
AB - Objectives: The aim of this study is to analyze the chronological development of macroscopic, microscopic and magnetic resonance imaging (MRI) findings in a rat model of Superior Mesenteric Venous (SMV) ligation, and to evaluate the role of MRI in the diagnosis of mesenteric venous thrombosis. Methods: Thirty adult Sprague-Dawley rats were used and divided in two different groups that underwent a different surgical model and a different monitoring of ischemic damage. Group I underwent macroscopical and histological observation; Group II underwent 7. T μMRI evaluation and histological analysis. Results: The first alterations occurred 30. min after SMV ligation and progressively worsened until the eighth hour. The morphological and MRI findings showed the same course. Conclusions: This study provides a systematic evaluation of early anatomopathological and MRI findings following the SMV ligation. MRI allows to identify the early pathological findings of venous mesenteric ischemia and allows to correlate those to the histopathological features. Our data suggest a relevant role of MRI in the diagnostic management of mesenteric venous thrombosis, allowing to non-invasively identify and characterize the histopathologic findings. So, thanks to these skills, its future application in early diagnosis of human mesenteric venous ischemia is supposable.
KW - Animal models
KW - Magnetic Resonance Imaging
KW - Mesenteric veins venous thrombosis
KW - Rats Sprague-Dawley
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U2 - 10.1016/j.mri.2012.08.003
DO - 10.1016/j.mri.2012.08.003
M3 - Article
C2 - 23102942
AN - SCOPUS:84875265387
VL - 31
SP - 408
EP - 413
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
SN - 0730-725X
IS - 3
ER -