8-Hydroxy-2-(Di-n-propylamino)tetralin (8-OH-DPAT) elicits eating in free-feeding rats by acting on central serotonin neurons

C. Bendotti, R. Samanin

Research output: Contribution to journalArticle

Abstract

A subcutaneous injection of 0.5 mg/kg 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a drug with high affinity for 5-hydroxytryptamine (5-HT1A) binding sites, substantially increased eating in non-deprived rats. Intraventricular injections of 5,7-dihydroxytryptamine (5,7-DHT), a neurotoxin for 5-HT neurons, also significantly increased eating in rats and antagonized the effect of 8-OH-DPAT. Microinjections of 8-OH-DPAT (0.5 and 1 μg) in the nuclei dorsalis and medianus raphe also significantly increased eating in rats. 8-OH-DPAT appears to stimulate eating by acting on 5-HT-containing neurons. These results are compatible wwith the hypothesis that a decrease in central 5-HT function disinhibits feeding.

Original languageEnglish
Pages (from-to)147-150
Number of pages4
JournalEuropean Journal of Pharmacology
Volume121
Issue number1
DOIs
Publication statusPublished - Feb 11 1986

Keywords

  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Feeding
  • Serotonin receptors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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