82. Determinants of plasma plasminogen activator inhibitor-1 antigen in subjects attending a metabolic ward

M. Margaglione, E. Celentano, E. Grandone, G. Vecchione, G. Cappucci, F. P. Mancini, G. Di Minno

Research output: Contribution to journalArticle

Abstract

Background: Plasminogen activator inhibitor-1 (PAI-1) is a determinant of vascular events. A guanine insertion/deletion polymorphism (4G/5G) modulates plasma levels of PAI-1. Moreover, the renin-angiotensin system has been reported to affect plasma PAI-1 levels in humans. Methods and Results: All the genotyping was carried out by polymerase chain reaction technique. In 208 subjects attending a metabolic ward, 5G/5G homozygous were associated with plasma PAI-1 levels lower than those of 4G/4G homozygous (29.4 vs 39.0 ng/dl, p=0.036). Plasma PAI-1 correlated with the 4G/5G genotype (p

Original languageEnglish
Pages (from-to)25
Number of pages1
JournalFibrinolysis
Volume10
Issue numberSUPPL. 1
Publication statusPublished - 1996

Fingerprint

Plasminogen Activator Inhibitor 1
Antigens
Guanine
Renin-Angiotensin System
Blood Vessels
Genotype
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Hematology

Cite this

Margaglione, M., Celentano, E., Grandone, E., Vecchione, G., Cappucci, G., Mancini, F. P., & Di Minno, G. (1996). 82. Determinants of plasma plasminogen activator inhibitor-1 antigen in subjects attending a metabolic ward. Fibrinolysis, 10(SUPPL. 1), 25.

82. Determinants of plasma plasminogen activator inhibitor-1 antigen in subjects attending a metabolic ward. / Margaglione, M.; Celentano, E.; Grandone, E.; Vecchione, G.; Cappucci, G.; Mancini, F. P.; Di Minno, G.

In: Fibrinolysis, Vol. 10, No. SUPPL. 1, 1996, p. 25.

Research output: Contribution to journalArticle

Margaglione, M, Celentano, E, Grandone, E, Vecchione, G, Cappucci, G, Mancini, FP & Di Minno, G 1996, '82. Determinants of plasma plasminogen activator inhibitor-1 antigen in subjects attending a metabolic ward', Fibrinolysis, vol. 10, no. SUPPL. 1, pp. 25.
Margaglione, M. ; Celentano, E. ; Grandone, E. ; Vecchione, G. ; Cappucci, G. ; Mancini, F. P. ; Di Minno, G. / 82. Determinants of plasma plasminogen activator inhibitor-1 antigen in subjects attending a metabolic ward. In: Fibrinolysis. 1996 ; Vol. 10, No. SUPPL. 1. pp. 25.
@article{87e4139437684e5b8fd8b48dbaa14768,
title = "82. Determinants of plasma plasminogen activator inhibitor-1 antigen in subjects attending a metabolic ward",
abstract = "Background: Plasminogen activator inhibitor-1 (PAI-1) is a determinant of vascular events. A guanine insertion/deletion polymorphism (4G/5G) modulates plasma levels of PAI-1. Moreover, the renin-angiotensin system has been reported to affect plasma PAI-1 levels in humans. Methods and Results: All the genotyping was carried out by polymerase chain reaction technique. In 208 subjects attending a metabolic ward, 5G/5G homozygous were associated with plasma PAI-1 levels lower than those of 4G/4G homozygous (29.4 vs 39.0 ng/dl, p=0.036). Plasma PAI-1 correlated with the 4G/5G genotype (p",
author = "M. Margaglione and E. Celentano and E. Grandone and G. Vecchione and G. Cappucci and Mancini, {F. P.} and {Di Minno}, G.",
year = "1996",
language = "English",
volume = "10",
pages = "25",
journal = "Fibrinolysis and Proteolysis",
issn = "1369-0191",
publisher = "Churchill Livingstone",
number = "SUPPL. 1",

}

TY - JOUR

T1 - 82. Determinants of plasma plasminogen activator inhibitor-1 antigen in subjects attending a metabolic ward

AU - Margaglione, M.

AU - Celentano, E.

AU - Grandone, E.

AU - Vecchione, G.

AU - Cappucci, G.

AU - Mancini, F. P.

AU - Di Minno, G.

PY - 1996

Y1 - 1996

N2 - Background: Plasminogen activator inhibitor-1 (PAI-1) is a determinant of vascular events. A guanine insertion/deletion polymorphism (4G/5G) modulates plasma levels of PAI-1. Moreover, the renin-angiotensin system has been reported to affect plasma PAI-1 levels in humans. Methods and Results: All the genotyping was carried out by polymerase chain reaction technique. In 208 subjects attending a metabolic ward, 5G/5G homozygous were associated with plasma PAI-1 levels lower than those of 4G/4G homozygous (29.4 vs 39.0 ng/dl, p=0.036). Plasma PAI-1 correlated with the 4G/5G genotype (p

AB - Background: Plasminogen activator inhibitor-1 (PAI-1) is a determinant of vascular events. A guanine insertion/deletion polymorphism (4G/5G) modulates plasma levels of PAI-1. Moreover, the renin-angiotensin system has been reported to affect plasma PAI-1 levels in humans. Methods and Results: All the genotyping was carried out by polymerase chain reaction technique. In 208 subjects attending a metabolic ward, 5G/5G homozygous were associated with plasma PAI-1 levels lower than those of 4G/4G homozygous (29.4 vs 39.0 ng/dl, p=0.036). Plasma PAI-1 correlated with the 4G/5G genotype (p

UR - http://www.scopus.com/inward/record.url?scp=33846684916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846684916&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 25

JO - Fibrinolysis and Proteolysis

JF - Fibrinolysis and Proteolysis

SN - 1369-0191

IS - SUPPL. 1

ER -