82. Determinants of plasma plasminogen activator inhibitor-1 antigen in subjects attending a metabolic ward

M. Margaglione; E. Celentano; E. Grandone; G. Vecchione; G. Cappucci; F. P. Mancini; G. Di Minno

82. Determinants of plasma plasminogen activator inhibitor-1 antigen in subjects attending a metabolic ward

M. Margaglione, E. Celentano, E. Grandone, G. Vecchione, G. Cappucci, F. P. Mancini, G. Di Minno

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Plasminogen activator inhibitor-1 (PAI-1) is a determinant of vascular events. A guanine insertion/deletion polymorphism (4G/5G) modulates plasma levels of PAI-1. Moreover, the renin-angiotensin system has been reported to affect plasma PAI-1 levels in humans. Methods and Results: All the genotyping was carried out by polymerase chain reaction technique. In 208 subjects attending a metabolic ward, 5G/5G homozygous were associated with plasma PAI-1 levels lower than those of 4G/4G homozygous (29.4 vs 39.0 ng/dl, p=0.036). Plasma PAI-1 correlated with the 4G/5G genotype (p

Original language	English
Pages (from-to)	25
Number of pages	1
Journal	Fibrinolysis
Volume	10
Issue number	SUPPL. 1
Publication status	Published - 1996

ASJC Scopus subject areas

Hematology

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title = "82. Determinants of plasma plasminogen activator inhibitor-1 antigen in subjects attending a metabolic ward",

abstract = "Background: Plasminogen activator inhibitor-1 (PAI-1) is a determinant of vascular events. A guanine insertion/deletion polymorphism (4G/5G) modulates plasma levels of PAI-1. Moreover, the renin-angiotensin system has been reported to affect plasma PAI-1 levels in humans. Methods and Results: All the genotyping was carried out by polymerase chain reaction technique. In 208 subjects attending a metabolic ward, 5G/5G homozygous were associated with plasma PAI-1 levels lower than those of 4G/4G homozygous (29.4 vs 39.0 ng/dl, p=0.036). Plasma PAI-1 correlated with the 4G/5G genotype (p",

author = "M. Margaglione and E. Celentano and E. Grandone and G. Vecchione and G. Cappucci and Mancini, {F. P.} and {Di Minno}, G.",

year = "1996",

language = "English",

volume = "10",

pages = "25",

journal = "Fibrinolysis and Proteolysis",

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T1 - 82. Determinants of plasma plasminogen activator inhibitor-1 antigen in subjects attending a metabolic ward

AU - Margaglione, M.

AU - Celentano, E.

AU - Grandone, E.

AU - Vecchione, G.

AU - Cappucci, G.

AU - Mancini, F. P.

AU - Di Minno, G.

PY - 1996

Y1 - 1996

N2 - Background: Plasminogen activator inhibitor-1 (PAI-1) is a determinant of vascular events. A guanine insertion/deletion polymorphism (4G/5G) modulates plasma levels of PAI-1. Moreover, the renin-angiotensin system has been reported to affect plasma PAI-1 levels in humans. Methods and Results: All the genotyping was carried out by polymerase chain reaction technique. In 208 subjects attending a metabolic ward, 5G/5G homozygous were associated with plasma PAI-1 levels lower than those of 4G/4G homozygous (29.4 vs 39.0 ng/dl, p=0.036). Plasma PAI-1 correlated with the 4G/5G genotype (p

AB - Background: Plasminogen activator inhibitor-1 (PAI-1) is a determinant of vascular events. A guanine insertion/deletion polymorphism (4G/5G) modulates plasma levels of PAI-1. Moreover, the renin-angiotensin system has been reported to affect plasma PAI-1 levels in humans. Methods and Results: All the genotyping was carried out by polymerase chain reaction technique. In 208 subjects attending a metabolic ward, 5G/5G homozygous were associated with plasma PAI-1 levels lower than those of 4G/4G homozygous (29.4 vs 39.0 ng/dl, p=0.036). Plasma PAI-1 correlated with the 4G/5G genotype (p

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