Abstract
Background: Plasminogen activator inhibitor-1 (PAI-1) is a determinant of vascular events. A guanine insertion/deletion polymorphism (4G/5G) modulates plasma levels of PAI-1. Moreover, the renin-angiotensin system has been reported to affect plasma PAI-1 levels in humans. Methods and Results: All the genotyping was carried out by polymerase chain reaction technique. In 208 subjects attending a metabolic ward, 5G/5G homozygous were associated with plasma PAI-1 levels lower than those of 4G/4G homozygous (29.4 vs 39.0 ng/dl, p=0.036). Plasma PAI-1 correlated with the 4G/5G genotype (p
Original language | English |
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Pages (from-to) | 25 |
Number of pages | 1 |
Journal | Fibrinolysis |
Volume | 10 |
Issue number | SUPPL. 1 |
Publication status | Published - 1996 |
ASJC Scopus subject areas
- Hematology