82. Determinants of plasma plasminogen activator inhibitor-1 antigen in subjects attending a metabolic ward

M. Margaglione, E. Celentano, E. Grandone, G. Vecchione, G. Cappucci, F. P. Mancini, G. Di Minno

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Plasminogen activator inhibitor-1 (PAI-1) is a determinant of vascular events. A guanine insertion/deletion polymorphism (4G/5G) modulates plasma levels of PAI-1. Moreover, the renin-angiotensin system has been reported to affect plasma PAI-1 levels in humans. Methods and Results: All the genotyping was carried out by polymerase chain reaction technique. In 208 subjects attending a metabolic ward, 5G/5G homozygous were associated with plasma PAI-1 levels lower than those of 4G/4G homozygous (29.4 vs 39.0 ng/dl, p=0.036). Plasma PAI-1 correlated with the 4G/5G genotype (p

Original languageEnglish
Pages (from-to)25
Number of pages1
JournalFibrinolysis
Volume10
Issue numberSUPPL. 1
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Hematology

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