Abstract
Background: Plasminogen activator inhibitor-1 (PAI-1) is a determinant of vascular events. A guanine insertion/deletion polymorphism (4G/5G) modulates plasma levels of PAI-1. Moreover, the renin-angiotensin system has been reported to affect plasma PAI-1 levels in humans. Methods and Results: All the genotyping was carried out by polymerase chain reaction technique. In 208 subjects attending a metabolic ward, 5G/5G homozygous were associated with plasma PAI-1 levels lower than those of 4G/4G homozygous (29.4 vs 39.0 ng/dl, p=0.036). Plasma PAI-1 correlated with the 4G/5G genotype (p
| Original language | English |
|---|---|
| Pages (from-to) | 25 |
| Number of pages | 1 |
| Journal | Fibrinolysis |
| Volume | 10 |
| Issue number | SUPPL. 1 |
| Publication status | Published - 1996 |
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ASJC Scopus subject areas
- Hematology
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82. Determinants of plasma plasminogen activator inhibitor-1 antigen in subjects attending a metabolic ward. / Margaglione, M.; Celentano, E.; Grandone, E.; Vecchione, G.; Cappucci, G.; Mancini, F. P.; Di Minno, G.
In: Fibrinolysis, Vol. 10, No. SUPPL. 1, 1996, p. 25.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 82. Determinants of plasma plasminogen activator inhibitor-1 antigen in subjects attending a metabolic ward
AU - Margaglione, M.
AU - Celentano, E.
AU - Grandone, E.
AU - Vecchione, G.
AU - Cappucci, G.
AU - Mancini, F. P.
AU - Di Minno, G.
PY - 1996
Y1 - 1996
N2 - Background: Plasminogen activator inhibitor-1 (PAI-1) is a determinant of vascular events. A guanine insertion/deletion polymorphism (4G/5G) modulates plasma levels of PAI-1. Moreover, the renin-angiotensin system has been reported to affect plasma PAI-1 levels in humans. Methods and Results: All the genotyping was carried out by polymerase chain reaction technique. In 208 subjects attending a metabolic ward, 5G/5G homozygous were associated with plasma PAI-1 levels lower than those of 4G/4G homozygous (29.4 vs 39.0 ng/dl, p=0.036). Plasma PAI-1 correlated with the 4G/5G genotype (p
AB - Background: Plasminogen activator inhibitor-1 (PAI-1) is a determinant of vascular events. A guanine insertion/deletion polymorphism (4G/5G) modulates plasma levels of PAI-1. Moreover, the renin-angiotensin system has been reported to affect plasma PAI-1 levels in humans. Methods and Results: All the genotyping was carried out by polymerase chain reaction technique. In 208 subjects attending a metabolic ward, 5G/5G homozygous were associated with plasma PAI-1 levels lower than those of 4G/4G homozygous (29.4 vs 39.0 ng/dl, p=0.036). Plasma PAI-1 correlated with the 4G/5G genotype (p
UR - http://www.scopus.com/inward/record.url?scp=33846684916&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846684916&partnerID=8YFLogxK
M3 - Article
VL - 10
SP - 25
JO - Fibrinolysis and Proteolysis
JF - Fibrinolysis and Proteolysis
SN - 1369-0191
IS - SUPPL. 1
ER -