TY - JOUR
T1 - 99mTc-2GAM
T2 - A tracer for renal imaging
AU - Gianolli, Luigi
AU - Dosio, Flaviano
AU - Matarrese, Mario
AU - Colombo, Fabio
AU - Cutler, Cathy
AU - Stepniak-Biniakiewicz, Danuta
AU - Deutsch, Edward
AU - Savi, Annarita
AU - Lucignani, Giovanni
AU - Fazio, Ferruccio
PY - 1996/11
Y1 - 1996/11
N2 - We propose a renal imaging agent, the 99mTc complex of the bidentate-N,S chelate N-(mercaptoacetyl)glycine (99mTc-2GAM), with the imaging characteristics of 99mTc-DMSA but a faster kidney uptake; chemical evidence supports the formulation of 99mTc-2GAM as [Tc(V)(O)(GAM)2]-. After biodistribution and toxicity studies in animals, 99mTc-2GAM was evaluated in five normal volunteers. 99mTc-2GAM is rapidly cleared from the blood (t( 1/4 ) = 9 min) and 50% of the ID is excreted in the urine in the first 2 h. Dynamic data show a rapid renal uptake that increases up to 1 h with no significant wash-out between 1 and 8 h. The uptake in each kidney ranges from 11.3% to 20.7% ID. Low, stable liver uptake is observed. No significant activity is detected in other organs. We showed no differences between 99mTc-2GAM and 99mTc-DMSA compared in three patients with unilateral kidney disease. We conclude that 99mTc-2GAM has good practical and dosimetric features for renal imaging.
AB - We propose a renal imaging agent, the 99mTc complex of the bidentate-N,S chelate N-(mercaptoacetyl)glycine (99mTc-2GAM), with the imaging characteristics of 99mTc-DMSA but a faster kidney uptake; chemical evidence supports the formulation of 99mTc-2GAM as [Tc(V)(O)(GAM)2]-. After biodistribution and toxicity studies in animals, 99mTc-2GAM was evaluated in five normal volunteers. 99mTc-2GAM is rapidly cleared from the blood (t( 1/4 ) = 9 min) and 50% of the ID is excreted in the urine in the first 2 h. Dynamic data show a rapid renal uptake that increases up to 1 h with no significant wash-out between 1 and 8 h. The uptake in each kidney ranges from 11.3% to 20.7% ID. Low, stable liver uptake is observed. No significant activity is detected in other organs. We showed no differences between 99mTc-2GAM and 99mTc-DMSA compared in three patients with unilateral kidney disease. We conclude that 99mTc-2GAM has good practical and dosimetric features for renal imaging.
KW - DMSA
KW - renal imaging
KW - renal mass
UR - http://www.scopus.com/inward/record.url?scp=0030273891&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030273891&partnerID=8YFLogxK
U2 - 10.1016/S0969-8051(96)00135-7
DO - 10.1016/S0969-8051(96)00135-7
M3 - Article
C2 - 9004280
AN - SCOPUS:0030273891
VL - 23
SP - 927
EP - 933
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
SN - 0969-8051
IS - 8
ER -