99mTc-2GAM: A tracer for renal imaging

Luigi Gianolli, Flaviano Dosio, Mario Matarrese, Fabio Colombo, Cathy Cutler, Danuta Stepniak-Biniakiewicz, Edward Deutsch, Annarita Savi, Giovanni Lucignani, Ferruccio Fazio

Research output: Contribution to journalArticlepeer-review

Abstract

We propose a renal imaging agent, the 99mTc complex of the bidentate-N,S chelate N-(mercaptoacetyl)glycine (99mTc-2GAM), with the imaging characteristics of 99mTc-DMSA but a faster kidney uptake; chemical evidence supports the formulation of 99mTc-2GAM as [Tc(V)(O)(GAM)2]-. After biodistribution and toxicity studies in animals, 99mTc-2GAM was evaluated in five normal volunteers. 99mTc-2GAM is rapidly cleared from the blood (t( 1/4 ) = 9 min) and 50% of the ID is excreted in the urine in the first 2 h. Dynamic data show a rapid renal uptake that increases up to 1 h with no significant wash-out between 1 and 8 h. The uptake in each kidney ranges from 11.3% to 20.7% ID. Low, stable liver uptake is observed. No significant activity is detected in other organs. We showed no differences between 99mTc-2GAM and 99mTc-DMSA compared in three patients with unilateral kidney disease. We conclude that 99mTc-2GAM has good practical and dosimetric features for renal imaging.

Original languageEnglish
Pages (from-to)927-933
Number of pages7
JournalNuclear Medicine and Biology
Volume23
Issue number8
DOIs
Publication statusPublished - Nov 1996

Keywords

  • DMSA
  • renal imaging
  • renal mass

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

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