99mTC-sestamibi breast imaging: Current status, new ideas and future perspectives

Nicoletta Urbano, Manuel Scimeca, Virginia Tancredi, Elena Bonanno, Orazio Schillaci

Research output: Contribution to journalReview article

Abstract

Here we proposed the most recent innovations in the use of Breast Specific Gamma Imaging with 99mTc-sestamibi for the management of breast cancer patients. To this end, we reported the recent discoveries concerning: a) the implementation of both instrumental devices and software, b) the biological mechanisms involved in the 99mTc-sestamibi uptake in breast cancer cells, c) the evaluation of Breast Specific Gamma Imaging with 99mTc-sestamibi as predictive markers of metastatic diseases. In this last case, we also reported preliminary data about the capability of Breast Specific Gamma Imaging with 99mTc-sestamibi to identify breast cancer lesions with high propensity to form bone metastatic lesions due to the presence of Breast Osteoblast-Like Cells.

Original languageEnglish
JournalSeminars in Cancer Biology
DOIs
Publication statusE-pub ahead of print - Jan 23 2020

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