Abstract
The International Registry of Lung Metastases defined a new staging system based on identified prognostic factors for long-term survival after metastasectomy. The aim of our study was to confirm the validity of the International Registry of Lung Metastases classification system in patients who underwent curative lung metastasectomy in a single center. Methods: We retrospectively reviewed 575 patients who underwent 708 lung metastasectomies from January 1998 to October 2008. Complete curative pulmonary resections were performed in 490 cases (85%). Three hundred seventy-two patients developed lung metastases from epithelial tumors, 80 from sarcomas, 27 from melanomas, and 11 from germ cell tumors. The mean disease-free interval (DFI) was 46.6 months. Open surgical resection was performed in 479 patients. One hundred eighty-five patients had a single-lung metastasis. Lymph node dissection was performed in 353 cases. Results: After a mean follow-up of 34 months, 247 patients (43%) had died. Multivariate analysis disclosed that completeness of resection (p <0.0001), patients with germ cell tumors (p = 0.04), and DFI ≥36 months (p = 0.01) were also associated with a better prognosis. The actuarial survival after complete metastasectomy was 74% at 2 years and 46% at 5 years. Conclusions: We confirmed completeness of surgery, histology, and DFI ≥36 months as independent prognostic factors. Number of metastases, presence of lymph node metastases, surgical approach, and number of metastasectomies did not statistically influence long-term survival.
| Original language | English |
|---|---|
| Pages (from-to) | 1373-1378 |
| Number of pages | 6 |
| Journal | Journal of Thoracic Oncology |
| Volume | 6 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2011 |
Fingerprint
Keywords
- Lung metastasis
- Monocenter study
- Radicality
- Surgery
- Survival
ASJC Scopus subject areas
- Oncology
- Pulmonary and Respiratory Medicine
Cite this
A 10-year single-center experience on 708 lung metastasectomies : The evidence of the "international registry of lung metastases". / Casiraghi, Monica; De Pas, Tommaso; Maisonneuve, Patrick; Brambilla, Daniela; Ciprandi, Barbara; Galetta, Domenico; Borri, Alessandro; Gasparri, Roberto; Petrella, Francesco; Tessitore, Adele; Guarize, Juliana; Donghi, Stefano Maria; Veronesi, Giulia; Solli, Piergiorgio; Spaggiari, Lorenzo.
In: Journal of Thoracic Oncology, Vol. 6, No. 8, 08.2011, p. 1373-1378.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A 10-year single-center experience on 708 lung metastasectomies
T2 - The evidence of the "international registry of lung metastases"
AU - Casiraghi, Monica
AU - De Pas, Tommaso
AU - Maisonneuve, Patrick
AU - Brambilla, Daniela
AU - Ciprandi, Barbara
AU - Galetta, Domenico
AU - Borri, Alessandro
AU - Gasparri, Roberto
AU - Petrella, Francesco
AU - Tessitore, Adele
AU - Guarize, Juliana
AU - Donghi, Stefano Maria
AU - Veronesi, Giulia
AU - Solli, Piergiorgio
AU - Spaggiari, Lorenzo
PY - 2011/8
Y1 - 2011/8
N2 - The International Registry of Lung Metastases defined a new staging system based on identified prognostic factors for long-term survival after metastasectomy. The aim of our study was to confirm the validity of the International Registry of Lung Metastases classification system in patients who underwent curative lung metastasectomy in a single center. Methods: We retrospectively reviewed 575 patients who underwent 708 lung metastasectomies from January 1998 to October 2008. Complete curative pulmonary resections were performed in 490 cases (85%). Three hundred seventy-two patients developed lung metastases from epithelial tumors, 80 from sarcomas, 27 from melanomas, and 11 from germ cell tumors. The mean disease-free interval (DFI) was 46.6 months. Open surgical resection was performed in 479 patients. One hundred eighty-five patients had a single-lung metastasis. Lymph node dissection was performed in 353 cases. Results: After a mean follow-up of 34 months, 247 patients (43%) had died. Multivariate analysis disclosed that completeness of resection (p <0.0001), patients with germ cell tumors (p = 0.04), and DFI ≥36 months (p = 0.01) were also associated with a better prognosis. The actuarial survival after complete metastasectomy was 74% at 2 years and 46% at 5 years. Conclusions: We confirmed completeness of surgery, histology, and DFI ≥36 months as independent prognostic factors. Number of metastases, presence of lymph node metastases, surgical approach, and number of metastasectomies did not statistically influence long-term survival.
AB - The International Registry of Lung Metastases defined a new staging system based on identified prognostic factors for long-term survival after metastasectomy. The aim of our study was to confirm the validity of the International Registry of Lung Metastases classification system in patients who underwent curative lung metastasectomy in a single center. Methods: We retrospectively reviewed 575 patients who underwent 708 lung metastasectomies from January 1998 to October 2008. Complete curative pulmonary resections were performed in 490 cases (85%). Three hundred seventy-two patients developed lung metastases from epithelial tumors, 80 from sarcomas, 27 from melanomas, and 11 from germ cell tumors. The mean disease-free interval (DFI) was 46.6 months. Open surgical resection was performed in 479 patients. One hundred eighty-five patients had a single-lung metastasis. Lymph node dissection was performed in 353 cases. Results: After a mean follow-up of 34 months, 247 patients (43%) had died. Multivariate analysis disclosed that completeness of resection (p <0.0001), patients with germ cell tumors (p = 0.04), and DFI ≥36 months (p = 0.01) were also associated with a better prognosis. The actuarial survival after complete metastasectomy was 74% at 2 years and 46% at 5 years. Conclusions: We confirmed completeness of surgery, histology, and DFI ≥36 months as independent prognostic factors. Number of metastases, presence of lymph node metastases, surgical approach, and number of metastasectomies did not statistically influence long-term survival.
KW - Lung metastasis
KW - Monocenter study
KW - Radicality
KW - Surgery
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=80051802370&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051802370&partnerID=8YFLogxK
U2 - 10.1097/JTO.0b013e3182208e58
DO - 10.1097/JTO.0b013e3182208e58
M3 - Article
C2 - 21642869
AN - SCOPUS:80051802370
VL - 6
SP - 1373
EP - 1378
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
SN - 1556-0864
IS - 8
ER -