A 10-year single-center experience on 708 lung metastasectomies: The evidence of the "international registry of lung metastases"

Research output: Contribution to journalArticle

Abstract

The International Registry of Lung Metastases defined a new staging system based on identified prognostic factors for long-term survival after metastasectomy. The aim of our study was to confirm the validity of the International Registry of Lung Metastases classification system in patients who underwent curative lung metastasectomy in a single center. Methods: We retrospectively reviewed 575 patients who underwent 708 lung metastasectomies from January 1998 to October 2008. Complete curative pulmonary resections were performed in 490 cases (85%). Three hundred seventy-two patients developed lung metastases from epithelial tumors, 80 from sarcomas, 27 from melanomas, and 11 from germ cell tumors. The mean disease-free interval (DFI) was 46.6 months. Open surgical resection was performed in 479 patients. One hundred eighty-five patients had a single-lung metastasis. Lymph node dissection was performed in 353 cases. Results: After a mean follow-up of 34 months, 247 patients (43%) had died. Multivariate analysis disclosed that completeness of resection (p <0.0001), patients with germ cell tumors (p = 0.04), and DFI ≥36 months (p = 0.01) were also associated with a better prognosis. The actuarial survival after complete metastasectomy was 74% at 2 years and 46% at 5 years. Conclusions: We confirmed completeness of surgery, histology, and DFI ≥36 months as independent prognostic factors. Number of metastases, presence of lymph node metastases, surgical approach, and number of metastasectomies did not statistically influence long-term survival.

Original languageEnglish
Pages (from-to)1373-1378
Number of pages6
JournalJournal of Thoracic Oncology
Volume6
Issue number8
DOIs
Publication statusPublished - Aug 2011

Fingerprint

Metastasectomy
Registries
Neoplasm Metastasis
Lung
Germ Cell and Embryonal Neoplasms
Survival
Lymph Node Excision
Sarcoma
Melanoma
Histology
Multivariate Analysis
Lymph Nodes

Keywords

  • Lung metastasis
  • Monocenter study
  • Radicality
  • Surgery
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

@article{1038b1198f184fe9a1bc65e5e310d036,
title = "A 10-year single-center experience on 708 lung metastasectomies: The evidence of the {"}international registry of lung metastases{"}",
abstract = "The International Registry of Lung Metastases defined a new staging system based on identified prognostic factors for long-term survival after metastasectomy. The aim of our study was to confirm the validity of the International Registry of Lung Metastases classification system in patients who underwent curative lung metastasectomy in a single center. Methods: We retrospectively reviewed 575 patients who underwent 708 lung metastasectomies from January 1998 to October 2008. Complete curative pulmonary resections were performed in 490 cases (85{\%}). Three hundred seventy-two patients developed lung metastases from epithelial tumors, 80 from sarcomas, 27 from melanomas, and 11 from germ cell tumors. The mean disease-free interval (DFI) was 46.6 months. Open surgical resection was performed in 479 patients. One hundred eighty-five patients had a single-lung metastasis. Lymph node dissection was performed in 353 cases. Results: After a mean follow-up of 34 months, 247 patients (43{\%}) had died. Multivariate analysis disclosed that completeness of resection (p <0.0001), patients with germ cell tumors (p = 0.04), and DFI ≥36 months (p = 0.01) were also associated with a better prognosis. The actuarial survival after complete metastasectomy was 74{\%} at 2 years and 46{\%} at 5 years. Conclusions: We confirmed completeness of surgery, histology, and DFI ≥36 months as independent prognostic factors. Number of metastases, presence of lymph node metastases, surgical approach, and number of metastasectomies did not statistically influence long-term survival.",
keywords = "Lung metastasis, Monocenter study, Radicality, Surgery, Survival",
author = "Monica Casiraghi and {De Pas}, Tommaso and Patrick Maisonneuve and Daniela Brambilla and Barbara Ciprandi and Domenico Galetta and Alessandro Borri and Roberto Gasparri and Francesco Petrella and Adele Tessitore and Juliana Guarize and Donghi, {Stefano Maria} and Giulia Veronesi and Piergiorgio Solli and Lorenzo Spaggiari",
year = "2011",
month = "8",
doi = "10.1097/JTO.0b013e3182208e58",
language = "English",
volume = "6",
pages = "1373--1378",
journal = "Journal of Thoracic Oncology",
issn = "1556-0864",
publisher = "Elsevier Inc.",
number = "8",

}

TY - JOUR

T1 - A 10-year single-center experience on 708 lung metastasectomies

T2 - The evidence of the "international registry of lung metastases"

AU - Casiraghi, Monica

AU - De Pas, Tommaso

AU - Maisonneuve, Patrick

AU - Brambilla, Daniela

AU - Ciprandi, Barbara

AU - Galetta, Domenico

AU - Borri, Alessandro

AU - Gasparri, Roberto

AU - Petrella, Francesco

AU - Tessitore, Adele

AU - Guarize, Juliana

AU - Donghi, Stefano Maria

AU - Veronesi, Giulia

AU - Solli, Piergiorgio

AU - Spaggiari, Lorenzo

PY - 2011/8

Y1 - 2011/8

N2 - The International Registry of Lung Metastases defined a new staging system based on identified prognostic factors for long-term survival after metastasectomy. The aim of our study was to confirm the validity of the International Registry of Lung Metastases classification system in patients who underwent curative lung metastasectomy in a single center. Methods: We retrospectively reviewed 575 patients who underwent 708 lung metastasectomies from January 1998 to October 2008. Complete curative pulmonary resections were performed in 490 cases (85%). Three hundred seventy-two patients developed lung metastases from epithelial tumors, 80 from sarcomas, 27 from melanomas, and 11 from germ cell tumors. The mean disease-free interval (DFI) was 46.6 months. Open surgical resection was performed in 479 patients. One hundred eighty-five patients had a single-lung metastasis. Lymph node dissection was performed in 353 cases. Results: After a mean follow-up of 34 months, 247 patients (43%) had died. Multivariate analysis disclosed that completeness of resection (p <0.0001), patients with germ cell tumors (p = 0.04), and DFI ≥36 months (p = 0.01) were also associated with a better prognosis. The actuarial survival after complete metastasectomy was 74% at 2 years and 46% at 5 years. Conclusions: We confirmed completeness of surgery, histology, and DFI ≥36 months as independent prognostic factors. Number of metastases, presence of lymph node metastases, surgical approach, and number of metastasectomies did not statistically influence long-term survival.

AB - The International Registry of Lung Metastases defined a new staging system based on identified prognostic factors for long-term survival after metastasectomy. The aim of our study was to confirm the validity of the International Registry of Lung Metastases classification system in patients who underwent curative lung metastasectomy in a single center. Methods: We retrospectively reviewed 575 patients who underwent 708 lung metastasectomies from January 1998 to October 2008. Complete curative pulmonary resections were performed in 490 cases (85%). Three hundred seventy-two patients developed lung metastases from epithelial tumors, 80 from sarcomas, 27 from melanomas, and 11 from germ cell tumors. The mean disease-free interval (DFI) was 46.6 months. Open surgical resection was performed in 479 patients. One hundred eighty-five patients had a single-lung metastasis. Lymph node dissection was performed in 353 cases. Results: After a mean follow-up of 34 months, 247 patients (43%) had died. Multivariate analysis disclosed that completeness of resection (p <0.0001), patients with germ cell tumors (p = 0.04), and DFI ≥36 months (p = 0.01) were also associated with a better prognosis. The actuarial survival after complete metastasectomy was 74% at 2 years and 46% at 5 years. Conclusions: We confirmed completeness of surgery, histology, and DFI ≥36 months as independent prognostic factors. Number of metastases, presence of lymph node metastases, surgical approach, and number of metastasectomies did not statistically influence long-term survival.

KW - Lung metastasis

KW - Monocenter study

KW - Radicality

KW - Surgery

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=80051802370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80051802370&partnerID=8YFLogxK

U2 - 10.1097/JTO.0b013e3182208e58

DO - 10.1097/JTO.0b013e3182208e58

M3 - Article

C2 - 21642869

AN - SCOPUS:80051802370

VL - 6

SP - 1373

EP - 1378

JO - Journal of Thoracic Oncology

JF - Journal of Thoracic Oncology

SN - 1556-0864

IS - 8

ER -