A 12-month prospective, observational study evaluating the impact of disease-modifying treatment on emotional burden in recently-diagnosed multiple sclerosis patients: The POSIDONIA study

Enrico Montanari, Mariarosa Rottoli, Davide Maimone, Paolo Confalonieri, Katrin Plewnia, Maura Frigo, Ada Francia, Antonello Pala, Nunzia Alessandra Losignore, Paolo Ragonese, Antonella Veneziano, POSIDONIA study group, Giovanni Meola

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Depression and anxiety are common among patients with multiple sclerosis (MS) and are frequently present at the time of MS diagnosis.

METHODS: POSIDONIA was a 12-month, observational, prospective study conducted in Italy to evaluate the impact of disease-modifying treatment (DMT) on emotional burden in patients with recently-diagnosed MS. The Hospital Anxiety and Depression Scale (HADS), specifically HADS anxiety (HADS-A) and depression (HADS-D) subscale scores, the Short-Form 36 Health Survey (SF-36) and the Impact of Event Scale - Revised (IES-R) were used to measure patient-reported outcomes. The Hamilton Depression Rating Scale (HDRS), HDRS-17, was used as a measure of healthcare provider-reported outcomes. The primary study outcome was change from baseline in feelings of anxiety and depression over 12months (via HADS).

RESULTS: Of 250 enrolled patients, 222 (88.8%) completed the study. At baseline, mean HADS total, HADS-A and HADS-D subscale scores were within the normal range. There were no significant changes over time in mean HADS total and HADS-A and HADS-D subscale scores, although the subgroup of patients with baseline scores indicative of anxiety or depression tended to improve over time. Both the HDRS and IES-R total scores improved over time, but there were no statistically significant changes in SF-36.

CONCLUSION: In the patient population of the POSIDONIA study depression and anxiety were present in a minority of patients thus not allowing to detect the impact of starting DMT. However DMT appears to have a positive effect in patients with measurable anxiety or depression at baseline.

Original languageEnglish
Pages (from-to)105-9
Number of pages5
JournalJournal of the Neurological Sciences
Volume364
DOIs
Publication statusPublished - May 15 2016

Keywords

  • Adolescent
  • Adult
  • Aged
  • Female
  • Humans
  • Immunologic Factors
  • Italy
  • Logistic Models
  • Male
  • Middle Aged
  • Mood Disorders
  • Multiple Sclerosis
  • Prospective Studies
  • Psychiatric Status Rating Scales
  • Psychometrics
  • Treatment Outcome
  • Young Adult
  • Journal Article
  • Multicenter Study
  • Observational Study
  • Research Support, Non-U.S. Gov't

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