A 12q13 translocation involving the HMGI-C gene in Richter transformation of a chronic lymphocytic leukemia

Basilia Santulli, Bernd Kazmierczak, Raffaela Napolitano, Irene Caliendo, Gennaro Chiappetta, Volkhard Rippe, Jörn Bullerdiek, Alfredo Fusco

Research output: Contribution to journalArticle

Abstract

We report a case of Richter transformation of a chronic lymphocytic leukemia with a 12q13 translocation involving the HMGI-C gene. Fluorescence in situ hybridization analysis with the use of two different cosmid pools spanning the entire HMGI-C region showed that the breakpoint on chromosome 12 was located in the HMGI-C gene, presumably within intron 3. In fact, the 3' region of HMGI-C had been translocated to a derivative chromosome 6. This translocation was not visible at the cytogenetic level. Immunohistochemical analysis performed on the bone marrow smear demonstrated the expression of the HMGI-C protein specifically in the blasts, suggesting that the aberrant expression of the HMGI-C gene might have an important role in the process of leukemogenesis. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume119
Issue number1
DOIs
Publication statusPublished - May 2000

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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  • Cite this

    Santulli, B., Kazmierczak, B., Napolitano, R., Caliendo, I., Chiappetta, G., Rippe, V., Bullerdiek, J., & Fusco, A. (2000). A 12q13 translocation involving the HMGI-C gene in Richter transformation of a chronic lymphocytic leukemia. Cancer Genetics and Cytogenetics, 119(1), 70-73. https://doi.org/10.1016/S0165-4608(99)00205-8