A 15-day course of donepezil modulates spectral EEG dynamics related to target auditory stimuli in young, healthy adult volunteers

Christopher Leroy, Jean Louis Bourriez, Kathy Dujardin, Behnam Molaee-Ardekani, Claudio Babiloni, Dominique Deplanque, Amélie Ponchel, Sophie Hennion, Lucie Plomhause, Hervé Devanne, Julie Deguil, Pierre Payoux, Olivier Blin, Déborah Méligne, Joëlle Micallef, Nicolas Chauveau, Laura Lanteaume, Céline Vervueren, François Guimont, Claire ThalamasCatherine Cassé-Perrot, Franck Rouby, Régis Bordet, Philippe Derambure

Research output: Contribution to journalArticle

Abstract

Objective: To identify possible electroencephalographic (EEG) markers of donepezil's effect on cortical activity in young, healthy adult volunteers at the group level. Methods: Thirty subjects were administered a daily dose of either 5. mg donepezil or placebo for 15. days in a double-blind, randomized, cross-over trial. The electroencephalogram during an auditory oddball paradigm was recorded from 58 scalp electrodes. Current source density (CSD) transformations were applied to EEG epochs. The event-related potential (ERP), inter-trial coherence (ITC: the phase consistency of the EEG spectrum) and event-related spectral perturbation (ERSP: the EEG power spectrum relative to the baseline) were calculated for the target (oddball) stimuli. Results: The donepezil and placebo conditions differed in terms of the changes in delta/theta/alpha/beta ITC and ERSP in various regions of the scalp (especially the frontal electrodes) but not in terms of latency and amplitude of the P300-ERP component. Conclusion: Our results suggest that ITC and ERSP analyses can provide EEG markers of donepezil's effects in young, healthy, adult volunteers at a group level. Significance: Novel EEG markers could be useful to assess the therapeutic potential of drug candidates in Alzheimer's disease in healthy volunteers prior to the initiation of Phase II/III clinical studies in patients.

Original languageEnglish
JournalClinical Neurophysiology
DOIs
Publication statusAccepted/In press - 2015

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Keywords

  • Donepezil
  • EEG markers
  • Event-related potential
  • Event-related spectral perturbation
  • Inter-trial coherence

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Sensory Systems

Cite this

Leroy, C., Bourriez, J. L., Dujardin, K., Molaee-Ardekani, B., Babiloni, C., Deplanque, D., Ponchel, A., Hennion, S., Plomhause, L., Devanne, H., Deguil, J., Payoux, P., Blin, O., Méligne, D., Micallef, J., Chauveau, N., Lanteaume, L., Vervueren, C., Guimont, F., ... Derambure, P. (Accepted/In press). A 15-day course of donepezil modulates spectral EEG dynamics related to target auditory stimuli in young, healthy adult volunteers. Clinical Neurophysiology. https://doi.org/10.1016/j.clinph.2015.11.018