A 15-min premedication for 1-h paclitaxel infusion: Optimizing patients' care

Alessandra Milani, Tommaso De Pas, Cristina Noberasco, Colette McDonnell, Livio Libutti, Ivan Limardi, Claudia Zencovich, Sabrina Boselli, Monica Bianchi, Filippo de Braud

Research output: Contribution to journalArticle

Abstract

Background: Paclitaxel is a plant product highly active in numerous cancers, but anaphylactic-like hypersensitivity reactions with it have been reported in about 28% of patients receiving the drug. Thirty to sixty minutes are needed to give a standard premedication with steroids and diphenhydramine, leading to patients and nurses' discomfort and stealing time from other infusional treatments. Patients and methods: Eighty-nine patients with advanced NSCLC never pre-treated with taxanes, received paclitaxel followed by gemcitabine on days 1, 8, 15 q4wks. Premedication consisted of prednisone 25 mg/os on day 0 and hydrocortisone plus clorfenamina maleato given intravenous on day 1 by a 15 min infusion immediately before paclitaxel administration. Results: Hypersensitivity reactions occurred in 3/341 (0.8%) cycles. In all three cases we observed severe dyspnoea and bronchospasm, that required treatment discontinuation but one was probably due to gemcitabine and another had a protracting time after premedication. Conclusions: A 15-min premedication infusion administered immediately before paclitaxel appeared to be highly effective in patients treated with 1 h-infusion paclitaxel.

Original languageEnglish
Pages (from-to)300-301
Number of pages2
JournalLung Cancer
Volume58
Issue number2
DOIs
Publication statusPublished - Nov 2007

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Keywords

  • Drug administration time
  • Hypersensitivity reaction
  • NSCLC
  • Paclitaxel
  • Premedication
  • Weekly administration

ASJC Scopus subject areas

  • Oncology

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