A 15-year epileptogenic period after perinatal brain injury

Francesco Pisani, Elena Pavlidis, Carlotta Facini, Chiara La Morgia, Carlo Fusco, Gaetano Cantalupo

Research output: Contribution to journalArticlepeer-review


Seizures are a frequent acute neurological event in the neonatal period. Up to 12 to 18% of all seizures in newborns are due to perinatal stroke and up to 39% of affected children can then develop epilepsy in childhood. We report the case of a young patient who presented stroke-related seizures in the neonatal period and then developed focal symptomatic epilepsy at 15 years of age, and in whom the epileptic focus was found to co-localize with the site of his ischemic brain lesion. Such a prolonged silent period before onset of remote symptomatic epilepsy has not previously been reported. This case suggests that newborns with seizures due to a neonatal stroke are at higher risk of epilepsy and that the epileptogenic process in these subjects can last longer than a decade.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalFunctional Neurology
Issue number1
Publication statusPublished - Jan 1 2017


  • Children
  • EEG
  • Epilepsy
  • Neonatal seizures
  • Perinatal stroke
  • Seizure

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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