A 15-year warranty period for asymptomatic individuals without coronary artery calcium: A prospective follow-up of 9,715 individuals

Valentina Valenti, Bríain Ó Hartaigh, Ran Heo, Iksung Cho, Joshua Schulman-Marcus, Heidi Gransar, Quynh A. Truong, Leslee J. Shaw, Joseph Knapper, Anita A. Kelkar, Pratik Sandesara, Fay Y. Lin, Sebastiano Sciarretta, Hyuk Jae Chang, Tracy Q. Callister, James K. Min

Research output: Contribution to journalArticle

Abstract

Objectives The aim of this study was to examine the long-term prognosis in asymptomatic individuals with a coronary artery calcium (CAC) score of 0 and its associated warranty period. Background Emerging evidence supports a CAC score of 0 as a favorable cardiovascular short-to intermediate-term prognostic factor. Methods A total of 9,715 individuals undergoing CAC imaging were stratified by age, Framingham risk score (FRS), and National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) categories and followed for a mean of 14.6 years (range 12.9 to 16.8 years). Cox regression, area under the receiver-operating characteristic curve, and net reclassification information were used to assess all-cause mortality, discrimination, and reclassification of a CAC score of 0 compared with the FRS and NCEP ATP III, respectively. A warranty period was pre-defined as

Original languageEnglish
Pages (from-to)900-909
Number of pages10
JournalJACC: Cardiovascular Imaging
Volume8
Issue number8
DOIs
Publication statusPublished - Aug 1 2015

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Keywords

  • computed tomography
  • coronary artery calcium
  • mortality
  • prognosis
  • warranty period

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Valenti, V., Ó Hartaigh, B., Heo, R., Cho, I., Schulman-Marcus, J., Gransar, H., Truong, Q. A., Shaw, L. J., Knapper, J., Kelkar, A. A., Sandesara, P., Lin, F. Y., Sciarretta, S., Chang, H. J., Callister, T. Q., & Min, J. K. (2015). A 15-year warranty period for asymptomatic individuals without coronary artery calcium: A prospective follow-up of 9,715 individuals. JACC: Cardiovascular Imaging, 8(8), 900-909. https://doi.org/10.1016/j.jcmg.2015.01.025